phosphatidylinositol 3-kinase complex, class III, type II
cytoplasmic vesicle
endosome
extrinsic component of membrane
phosphatidylinositol 3-kinase complex, class III, type I
phagocytic vesicle
mitochondrion
protein-containing complex
Biological process
negative regulation of cell population proliferation
response to hypoxia
cellular response to aluminum ion
response to vitamin E
lysosome organization
cell cycle
positive regulation of phosphatidylinositol 3-kinase signaling
cellular response to glucose starvation
cellular defense response
cytokinesis
cellular response to epidermal growth factor stimulus
cell division
receptor catabolic process
autophagy of nucleus
cellular response to nitrogen starvation
viral process
late endosome to vacuole transport
apoptotic process
cytoplasm to vacuole transport by the Cvt pathway
endocytosis
engulfment of apoptotic cell
positive regulation of attachment of mitotic spindle microtubules to kinetochore
amyloid-beta metabolic process
neuron development
defense response to virus
response to other organism
mitotic metaphase plate congression
regulation of catalytic activity
negative regulation of reactive oxygen species metabolic process
regulation of cytokinesis
negative regulation of apoptotic process
negative regulation of cell death
autophagosome assembly
macroautophagy
human ageing
response to iron(II) ion
response to lead ion
protein deubiquitination
response to nutrient levels
cellular response to amino acid starvation
cellular response to hydrogen peroxide
cellular response to copper ion
negative regulation of lysosome organization
positive regulation of autophagosome assembly
autophagy of mitochondrion
mitophagy
autophagy
positive regulation of autophagy
response to mitochondrial depolarisation
early endosome to late endosome transport
negative regulation of autophagy
positive regulation of cardiac muscle hypertrophy
negative regulation of autophagosome assembly
positive regulation of intrinsic apoptotic signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8678
56208
Ensembl
ENSG00000126581
ENSMUSG00000035086
UniProt
Q14457
O88597
RefSeq (mRNA)
NM_001313998 NM_001313999 NM_001314000 NM_003766
NM_019584 NM_001359819 NM_001359820 NM_001359821
RefSeq (protein)
NP_001300927 NP_001300928 NP_001300929 NP_003757
NP_062530 NP_001346748 NP_001346749 NP_001346750
Location (UCSC)
Chr 17: 42.81 – 42.83 Mb
Chr 11: 101.18 – 101.19 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Beclin-1 is a protein that in humans is encoded by the BECN1 gene.[5][6] Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode.[7] This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.
^ abcGRCh38: Ensembl release 89: ENSG00000126581 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000035086 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. (November 1998). "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein". Journal of Virology. 72 (11): 8586–96. doi:10.1128/JVI.72.11.8586-8596.1998. PMC 110269. PMID 9765397.
^Takacs-Vellai K, Vellai T, Puoti A, Passannante M, Wicky C, Streit A, et al. (August 2005). "Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans". Current Biology. 15 (16): 1513–7. Bibcode:2005CBio...15.1513T. doi:10.1016/j.cub.2005.07.035. PMID 16111945. S2CID 7404414.
Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and...
and type 2 diabetes share four loci, namely, ACTR2, ERLIN1, TRMT112, and BECN1, which are connected via inflammatory NF-κB pathway. While no cure is available...
Neurovirulence factor. Antagonizes PKR by de-phosphorylating eIF4a. Binds to BECN1 and inactivates autophagy. LAT LRP1, LRP2 P17588 P17589 Latency-associated...
sequence-specific manner.[supplied by OMIM] GOPC has been shown to interact with GRID2, BECN1, RHOQ, ACCN3, Cystic fibrosis transmembrane conductance regulator and CSPG5...
Shi C, Ye L, Sun W, Wang L, Liang H, Ou J (2016). "ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2"...