MAPK15 information

MAPK15
Identifiers
Aliases	MAPK15, ERK7, ERK8, mitogen-activated protein kinase 15
External IDs	MGI: 2652894; HomoloGene: 16371; GeneCards: MAPK15; OMA:MAPK15 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,722,458 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	75,871,003 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left lobe of thyroid gland; ; left uterine tube; ; right lobe of thyroid gland; ; right lung; ; anterior pituitary; ; skin of abdomen; ; upper lobe of left lung; ; body of pancreas; ; canal of the cervix;
	Top expressed in
	spermatocyte; ; rib; ; spermatid; ; seminiferous tubule; ; proximal tubule; ; islet of Langerhans; ; esophagus; ; lip; ; respiratory epithelium; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; SH3 domain binding; MAP kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity; kinase activity; chromatin binding;
Cellular component	intracellular anatomical structure; extracellular region; nucleus; cytoplasm; autophagosome; centriole; cell-cell junction; axoneme; ciliary basal body; Golgi apparatus; meiotic spindle; spindle; cytoskeleton; bicellular tight junction; cell junction; cytoplasmic vesicle; cell projection;
Biological process	positive regulation of telomere capping; phosphorylation; positive regulation of telomere maintenance via telomerase; protein phosphorylation; positive regulation of telomerase activity; MAPK cascade; protein autophosphorylation; regulation of gene expression; regulation of autophagy; protein localization to ciliary transition zone; regulation of COPII vesicle coating; endoplasmic reticulum organization; negative regulation of cell migration; dopamine uptake; regulation of cilium assembly; positive regulation of metaphase/anaphase transition of meiosis I; positive regulation of spindle assembly; cellular response to DNA damage stimulus; positive regulation of cell population proliferation; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	225689
	332110
	ENSG00000181085; ENSG00000274205
	ENSMUSG00000063704
	Q8TD08
	Q80Y86
	NM_139021
	NM_177922
	NP_620590
	NP_808590
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 gene.^[5]^[6]

Evolutionarily, MAPK15 is conserved in a number of species, including P. troglodytes, B. taurus, M. musculus, R. norvegicus, D. rerio, D. melanogaster, C. elegans, and X. laevis.^[6]

^ ^a ^b ^c ENSG00000274205 GRCh38: Ensembl release 89: ENSG00000181085, ENSG00000274205 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063704 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Abe MK, Saelzler MP, Espinosa R, Kahle KT, Hershenson MB, Le Beau MM, Rosner MR (May 2002). "ERK8, a new member of the mitogen-activated protein kinase family". The Journal of Biological Chemistry. 277 (19): 16733–43. doi:10.1074/jbc.M112483200. PMID 11875070.
^ ^a ^b "Entrez Gene: MAPK15 mitogen-activated protein kinase 15".

[refGRCh38Ensembl-1] ENSG00000274205 GRCh38: Ensembl release 89: ENSG00000181085, ENSG00000274205 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063704 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11875070-5] Abe MK, Saelzler MP, Espinosa R, Kahle KT, Hershenson MB, Le Beau MM, Rosner MR (May 2002). "ERK8, a new member of the mitogen-activated protein kinase family". The Journal of Biological Chemistry. 277 (19): 16733–43. doi:10.1074/jbc.M112483200. PMID 11875070.

[entrez-6] "Entrez Gene: MAPK15 mitogen-activated protein kinase 15".

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