Protein-coding gene in the species Homo sapiens
MAD2L2 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK5
Identifiers Aliases MAD2L2 , MAD2B, POLZ2, REV7, MAD2 mitotic arrest deficient-like 2 (yeast), mitotic arrest deficient 2 like 2, FANCVExternal IDs OMIM: 604094; MGI: 1919140; HomoloGene: 4624; GeneCards: MAD2L2; OMA:MAD2L2 - orthologs Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,674,480 bp[1] End 11,691,650 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 148,130,384 bp[2] End 148,145,699 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence left testis right testis granulocyte gastrocnemius muscle stromal cell of endometrium ventricular zone muscle of thigh right lobe of liver body of pancreas
Top expressed in genital tubercle seminiferous tubule tail of embryo spermatocyte zygote ventricular zone morula secondary oocyte external carotid artery neural tube
More reference expression data
BioGPS
Gene ontology Molecular function
JUN kinase binding
protein binding
Cellular component
cytoplasm
spindle
nucleoplasm
zeta DNA polymerase complex
anaphase-promoting complex
cytoskeleton
nucleus
nucleolus
cytosol
chromosome
site of double-strand break
Biological process
DNA damage response, signal transduction resulting in transcription
regulation of transcription, DNA-templated
negative regulation of protein catabolic process
actin filament organization
negative regulation of cell-cell adhesion mediated by cadherin
negative regulation of transcription by competitive promoter binding
negative regulation of transcription by RNA polymerase II
negative regulation of DNA-binding transcription factor activity
transcription, DNA-templated
mitotic spindle assembly checkpoint signaling
positive regulation of peptidyl-serine phosphorylation
error-prone translesion synthesis
cellular response to DNA damage stimulus
cell division
positive regulation of transcription, DNA-templated
negative regulation of transcription regulatory region DNA binding
double-strand break repair
regulation of cell growth
cell cycle
negative regulation of canonical Wnt signaling pathway
negative regulation of epithelial to mesenchymal transition
negative regulation of ubiquitin protein ligase activity
DNA repair
positive regulation of isotype switching
negative regulation of double-strand break repair via homologous recombination
positive regulation of double-strand break repair via nonhomologous end joining
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 1: 11.67 – 11.69 Mb Chr 4: 148.13 – 148.15 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.[5] [6]
^ a b c GRCh38: Ensembl release 89: ENSG00000116670 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029003 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C (Aug 1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics . 58 (2): 181–187. doi:10.1006/geno.1999.5831 . PMID 10366450.
^ "Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)".
Last Update: 2023-12-27T22:38:23Z
checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene. MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents...
Word Count : 1003
Last Update: 2024-06-11T08:30:12Z
represent candidates for further evaluation." REV3L in turn interacts with MAD2L2 on Chromosome 1; thus the inheritance patter is likely to be more complicated...
Word Count : 2229
Last Update: 2024-04-12T15:42:16Z
sensitivity to microtubule poisons. The human orthologues of Mad2 (MAD2L1 and MAD2L2 ) were first cloned in a search for human cDNAs that would rescue the microtubule...
Word Count : 1150
Last Update: 2023-06-07T14:31:13Z
Humans proteins containing this domain include: HORMAD1, HORMAD2, MAD2L1, MAD2L2 He X, Patterson TE, Sazer S (1997). "The Schizosaccharomyces pombe spindle...
Word Count : 202
Last Update: 2024-06-13T09:35:29Z
polymerase, is made of two subunits Rev3, the catalytic subunit, and Rev7 (MAD2L2 ), which increases the catalytic function of the polymerase, and is involved...
Word Count : 7090
Last Update: 2023-12-03T01:25:33Z
two-hybrid screenings have found C20orf196 to interact with PRMT1, QARS, MAD2L2 , and CUL3. C20orf196 functionally interacts with REV7, SHLD2, and SHLD3...
Word Count : 1446
Last Update: 2023-08-18T22:04:46Z
proteins, especially Pol ζ (Rev3/Rev7). REV1 has been shown to interact with MAD2L2 . It is believed that Rev1 may interact with PCNA, once ubiquitylated due...
Word Count : 1092
Last Update: 2023-03-03T22:35:24Z
chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome...
Word Count : 1975
Last Update: 2023-09-07T12:47:59Z
force of evolution.[citation needed] REV3L has been shown to interact with MAD2L2 . GRCh38: Ensembl release 89: ENSG00000009413 – Ensembl, May 2017 GRCm38:...
Word Count : 921
Last Update: 2024-01-03T02:24:39Z
identified, encoding distinct isoforms. ADAM9 has been shown to interact with: MAD2L2 , SH3GL2, and SNX9 ENSG00000282230 GRCh38: Ensembl release 89: ENSG00000168615...
Word Count : 1218
Last Update: 2024-04-28T06:05:23Z
chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2 ". Cell Cycle. 17 (1): 124–136. doi:10.1080/15384101.2017.1404210. ISSN 1538-4101...
Word Count : 3540