positive regulation of mitotic cell cycle spindle assembly checkpoint
negative regulation of protein catabolic process
mitotic cell cycle checkpoint signaling
negative regulation of apoptotic process
cell division
mitotic sister chromatid segregation
cell cycle
anaphase-promoting complex-dependent catabolic process
negative regulation of mitotic cell cycle
mitotic spindle assembly checkpoint signaling
negative regulation of ubiquitin protein ligase activity
regulation of mitotic cell cycle phase transition
ubiquitin-dependent protein catabolic process
establishment of mitotic spindle orientation
establishment of centrosome localization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4085
56150
Ensembl
ENSG00000164109
ENSMUSG00000029910
UniProt
Q13257
Q9Z1B5
RefSeq (mRNA)
NM_002358
NM_019499 NM_001355624
RefSeq (protein)
NP_002349
NP_062372 NP_001342553
Location (UCSC)
Chr 4: 120.06 – 120.07 Mb
Chr 6: 66.51 – 66.52 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000164109 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029910 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Li Y, Benezra R (October 1996). "Identification of a human mitotic checkpoint gene: hsMAD2". Science. 274 (5285): 246–8. Bibcode:1996Sci...274..246L. doi:10.1126/science.274.5285.246. PMID 8824189. S2CID 41334564.
^Xu L, Deng HX, Yang Y, Xia JH, Hung WY, Siddque T (November 1997). "Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization". Cytogenet. Cell Genet. 78 (1): 63–4. doi:10.1159/000134631. PMID 9345911.
checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene. MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents...
Insulin receptor has been shown to interact with ENPP1, GRB10, GRB7, IRS1, MAD2L1, PRKCD, PTPN11, and SH2B1. GRCh38: Ensembl release 89: ENSG00000171105 –...
confer sensitivity to microtubule poisons. The human orthologues of Mad2 (MAD2L1 and MAD2L2) were first cloned in a search for human cDNAs that would rescue...
the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Some...
MAD2L1-binding protein is a protein that in humans is encoded by the MAD2L1BP gene. The protein encoded by this gene was identified as a binding protein...
of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic...
interact with: ANAPC7 BUB1B, CDC16, CDC27, Cyclin A1, FBXO5, HDAC1, HDAC2, and MAD2L1. However, the most important interaction of CDC20 is with the Anaphase Promoting...
the metaphase plate. MAD2L2 is a homolog of MAD2L1. MAD2L2 has been shown to interact with: ADAM9, MAD2L1, REV1, and REV3L. GRCh38: Ensembl release 89:...
cellular adhesion molecule. ADAM17 has been shown to interact with: DLG1 MAD2L1, and MAPK1. The localization of ADAM17 is speculated to be an important...
Z.; Davis, S.; Lutum-Jehle, A.; Takemoto, D. (2017). "Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell...
promote cancer progression. UBD has been shown to interact with NUB1 and MAD2L1. ENSG00000231968, ENSG00000206468, ENSG00000206513, ENSG00000224654, ENSG00000213886...
Global Information
