Reaction(s) leading to production of (phospho)lipid peroxides
"LOPs" redirects here. For other uses, see LOP (disambiguation).
Lipid peroxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids,[1] resulting in the formation of peroxide and hydroperoxide derivatives.[2] It occurs when free radicals, specifically reactive oxygen species (ROS), interact with lipids within cell membranes, typically polyunsaturated fatty acids (PUFAs) as they have carbon–carbon double bonds. This reaction leads to the formation of lipid radicals, collectively referred to as lipid peroxides or lipid oxidation products (LOPs), which in turn react with other oxidizing agents, leading to a chain reaction that results in oxidative stress and cell damage.
In pathology and medicine, lipid peroxidation plays a role in cell damage which has broadly been implicated in the pathogenesis of various diseases and disease states, including ageing,[3][4] whereas in food science lipid peroxidation is one of many pathways to rancidity.[5]
^Izdebska, Joanna (2016), "Aging and Degradation of Printed Materials", Printing on Polymers, Elsevier, pp. 353–370, doi:10.1016/b978-0-323-37468-2.00022-1, ISBN 978-0-323-37468-2, retrieved 2024-03-15
^Ayala, Antonio; Muñoz, Mario F.; Argüelles, Sandro (2014). "Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal". Oxidative Medicine and Cellular Longevity. 2014: 1–31. doi:10.1155/2014/360438. ISSN 1942-0900. PMC 4066722. PMID 24999379.
^Porter, Ned A.; Caldwell, Sarah E.; Mills, Karen A. (1995). "Mechanisms of free radical oxidation of unsaturated lipids". Lipids. 30 (4): 277–290. doi:10.1007/BF02536034. PMID 7609594. S2CID 4051766.
^Mozuraityte, R.; Kristinova, V.; Rustad, T. (2016-01-01), "Oxidation of Food Components", in Caballero, Benjamin; Finglas, Paul M.; Toldrá, Fidel (eds.), Encyclopedia of Food and Health, Oxford: Academic Press, pp. 186–190, doi:10.1016/b978-0-12-384947-2.00508-0, ISBN 978-0-12-384953-3, archived from the original on 2022-05-04, retrieved 2024-03-15
and 26 Related for: Lipid peroxidation information
Lipidperoxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids, resulting in the formation of peroxide...
living organisms are lipidperoxidation in cell membranes and propagation of excitation of neurons in epilepsy. Nonenzymatic peroxidation occurs through the...
of oxidative stress is lipidperoxidation, or the presence of reactive peroxide groups on fatty acid molecules. These peroxides disrupt the integrity of...
glutathione-dependent antioxidant defenses, resulting in unchecked lipidperoxidation and eventual cell death. Lipophilic antioxidants and iron chelators...
able to effectively delay the development of oxidative rancidity. Lipidperoxidation is considered to be a major reason for the deterioration of quality...
the more vulnerable it is to lipidperoxidation (rancidity). Antioxidants can protect unsaturated fat from lipidperoxidation. In chemical analysis, fats...
Deuterium-reinforced lipids can be used for the protection of living cells by slowing the chain reaction of lipidperoxidation. The lipid bilayer of the cell...
readily oxidized. Research into how vitamin E prevents the process of lipidperoxidation led to the identification of antioxidants as reducing agents that...
system function to suppress this macrophage action. Involvement of lipidperoxidation chain reaction in atherogenesis triggered research on the protective...
Thiobarbituric acid reactive substances (TBARS) are formed as a byproduct of lipidperoxidation (i.e. as degradation products of fats) which can be detected by the...
sodium salt of the enolate (m.p. 245 °C). Malondialdehyde results from lipidperoxidation of polyunsaturated fatty acids. It is a prominent product in thromboxane...
effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Oxidative stress from...
caused by sources such as reactive oxygen species, free radicals, peroxides, lipidperoxides, and heavy metals. It is a tripeptide with a gamma peptide linkage...
prepared in this way. Polyunsaturated fatty acids are susceptible to lipidperoxidation, far moreso than monounsaturated or saturated analogues. The basis...
the more vulnerable it is to lipidperoxidation (rancidity). Antioxidants can protect unsaturated fat from lipidperoxidation. Linseed oil and related oils...
transport by lipidperoxidation. Conjugated double bonds in nystatin's structure steal electron density from ergosterol in fungal cell membranes. Lipid peroxidation...
LPO may refer to: Lipidperoxidation LPO-50, a flamethrower built by the Soviet Union Law practice optimization Landing Page Optimization Leading Petty...
Hirotoshi (January 1999). "Inhibition of Iron/Ascorbate-Induced LipidPeroxidation by an N-Terminal Peptide of Bovine Lactoferrin and Its Acylated Derivatives"...
phospholipid hydroperoxidase that protects cells against membrane lipidperoxidation. GPX4 was first discovered in biochemistry laboratories of the University...
used as a reagent in assaying malondialdehyde (the TBARS assay of lipidperoxidation). It is also used in Kodak Fogging Developer FD-70, part of the Kodak...
part of the Maillard reaction. These products accelerate membrane lipidperoxidation, causing oxidative stress to cells that come in contact with them...
organisms include excitation of neurons in epilepsy and lipidperoxidation. In peroxidation, a lipid radical reacts with oxygen to form a peroxyl radical...
at trace concentrations. Aluminium toxicity causes an increase in lipidperoxidation, with most damage occurring in the brain. A recent review of studies...
cells by slowing the chain reaction due to isotope effect on lipidperoxidation. The lipid bilayer of the cell and organelle membranes contain polyunsaturated...
"Modulation of phospholipid asymmetry in synaptosomal membranes by the lipidperoxidation products, 4-hydroxynonenal and acrolein: implications for Alzheimer's...
to have cytotoxic properties as well as antioxidant properties on lipidperoxidation. Tebufenozide, sold under the Bayer trademark MIMIC, has ecdysteroid...
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