This article is about the health risks of blood cholesterol. For the risks of saturated fat, see Saturated fat and cardiovascular disease.
The lipid hypothesis (also known as the cholesterol hypothesis) is a medical theory postulating a link between blood cholesterol levels and the occurrence of cardiovascular disease. A summary from 1976 described it as: "measures used to lower the plasma lipids in patients with hyperlipidemia will lead to reductions in new events of coronary heart disease".[1] It states, more concisely, that "decreasing blood cholesterol [...] significantly reduces coronary heart disease".[2]
As of 2023, there is international clinical acceptance of the lipid hypothesis.[3][4][5][6]
^Ahrens EH Jr (July 1976). "The management of hyperlipidemia: whether, rather than how". Ann Intern Med. 85 (1): 87–93. doi:10.7326/0003-4819-85-1-87. PMID 779574.
^Steinberg D (2006). "An interpretive history of the cholesterol controversy, part IV: The 1984 coronary primary prevention trial ends it - almost". J Lipid Res. 47 (1): 1–14. doi:10.1194/jlr.R500014-JLR200. PMID 16227628.
^Cite error: The named reference European was invoked but never defined (see the help page).
^Linton MF, Yancey PG, Davies SS, et al. (3 January 2019). "The Role of Lipids and Lipoproteins in Atherosclerosis". Endotext. PMID 26844337.
^Duarte Lau F, Giugliano RP (July 2022). "Lipoprotein(a) and its Significance in Cardiovascular Disease: A Review". JAMA Cardiology. 7 (7): 760–769. doi:10.1001/jamacardio.2022.0987. PMID 35583875.
^"World Heart Report 2023: Confronting the World's Number One Killer" (PDF). World Heart Federation. 2023. Retrieved 22 January 2024.
The lipidhypothesis (also known as the cholesterol hypothesis) is a medical theory postulating a link between blood cholesterol levels and the occurrence...
Miller and Smith suggested the critical volume hypothesis also called lipid bilayer expansion hypothesis. They assumed that bulky and hydrophobic anaesthetic...
and coronary heart disease via the mechanisms described by the lipidhypothesis. As lipid-lowering medications, statins are effective in lowering LDL cholesterol...
The film seeks to refute both the documentary Super Size Me and the lipidhypothesis, a theory of nutrition started in the early 1950s in the United States...
has become known for querying the scientific consensus regarding the lipidhypothesis. Ravnskov was born in Copenhagen, Denmark, and received his medical...
Blood lipids (or blood fats) are lipids in the blood, either free or bound to other molecules. They are mostly transported in a phospholipid capsule,...
supplemented with phytosterols have also been questioned. According to the lipidhypothesis, elevated levels of cholesterol in the blood lead to atherosclerosis...
World Health Organization in Geneva, Keys presented his diet-lipid-heart disease hypothesis. As part of his argument, he presented a correlation between...
not considered as a possible contributor to coronary heart disease. Lipidhypothesis Atherosclerosis Blackburn Henry (1975). "Contrasting Professional Views...
the Cholesterol Treatment Trialists' Collaboration has confirmed the lipidhypothesis. The NLA publishes the Journal of Clinical Lipidology. In 2019, the...
disease (CHD), the other being the lipidhypothesis. Although an ongoing debate involving connection between dietary lipids and CHD sometimes portrays the...
functional cell membranes. According to this biological model, there is a lipid bilayer (two molecules thick layer consisting primarily of amphipathic phospholipids)...
1950s, White collaborated with Ancel Keys in developing the diet-heart hypothesis. White authored the Foreword to Ancel Key's 1959 book Eat Well and Stay...
authored a 2017 article in The Pharmaceutical Journal which disputes the Lipidhypothesis, the link between blood cholesterol levels and occurrence of heart...
relation with increased risk of cardiovascular disease (the so-called lipidhypothesis). However, high cholesterol may be caused by many factors. Other indicators...
cardiologist who works in Albuquerque, New Mexico. He has challenged the lipidhypothesis and has disputed the efficiency of statin therapy. Dubroff also disputes...
describes his conversion to LCHF dieting, and writes that in his view the lipidhypothesis is the "biggest mistake in modern medicine". He details his struggles...
gradients taken together can be expressed as an electrochemical gradient. Lipid bilayers of biological membranes, however, are barriers for ions. This is...
Ernest Overton proposed that cell membranes were made of lipids. The lipid bilayer hypothesis, proposed in 1925 by Gorter and Grendel, created speculation...
inversely proportional to its lipid solubility (oil:gas coefficient), in most cases. This is the Meyer-Overton hypothesis put forward in 1899–1901 by Hans...
The Purple Earth Hypothesis (PEH) is an astrobiological hypothesis, first proposed by molecular biologist Shiladitya DasSarma in 2007, that the earliest...
development of chemiosmotic energy across lipid membranes if at a terrestrial origin. The RNA world hypothesis describes an early Earth with self-replicating...
components into short peptide and lipid chains as well as short RNA-like chains of nucleotides. The RNA world hypothesis, if true, has important implications...
the plasma membrane. To examine their hypothesis, they performed an experiment in which they extracted lipids from a known number of red blood cells...
types can be distinguished: The fibro-lipid (fibro-fatty) plaque is characterized by an accumulation of lipid-laden cells underneath the intima of the...
Global Information