Method for oxidizing aldehydes to carboxylic acids
Lindgren oxidation
Named after
Bengt O. Lindgren
Reaction type
Organic redox reaction
Identifiers
RSC ontology ID
RXNO:0000287
Lindgren oxidation is a selective method for oxidizing aldehydes to carboxylic acids.[1] The reaction is named after Bengt O. Lindgren.
The oxidation takes place in water containing solvent mixtures under slightly acidic conditions (pH 3–5) with sodium chlorite as oxidizer. To avoid complicated oxidation reactions the hypochlorite, which is formed in the reaction, has to be removed from the reaction mixture by scavengers. In the original publication, sulfamic acid and resorcinol were used.[1] George A. Kraus and co-workers were the first to use 2-methyl-2-butene as scavenger under buffered conditions for the oxidation of an aliphatic and an α,β-unsaturated aldehyde.[2][3] Later hydrogen peroxide also proved to work to remove the hypochlorite.[4]
^ abLindgren, Bengt O.; Nilsson, Torsten (1973). "Preparation of Carboxylic Acids from Aldehydes (Including Hydroxylated Benzaldehydes) by Oxidation with Chlorite". Acta Chemica Scandinavica. 27: 888–890. doi:10.3891/acta.chem.scand.27-0888.
^George A. Kraus; Bruce Roth (1980). "Synthetic studies toward verrucarol. 2. Synthesis of the AB ring system". The Journal of Organic Chemistry. 45 (24): 4825–4830. doi:10.1021/jo01312a004.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^George A. Kraus; Michael J. Taschner (1980). "Model studies for the synthesis of quassinoids. 1. Construction of the BCE ring system". The Journal of Organic Chemistry. 45 (6): 1175–1176. doi:10.1021/jo01294a058.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Enrico Dalcanale; Fernando Montanari (1986). "Selective oxidation of aldehydes to carboxylic acids with sodium chlorite-hydrogen peroxide". The Journal of Organic Chemistry. 51 (4): 567–569. doi:10.1021/jo00354a037.{{cite journal}}: CS1 maint: multiple names: authors list (link)
and 27 Related for: Lindgren oxidation information
Lindgrenoxidation is a selective method for oxidizing aldehydes to carboxylic acids. The reaction is named after Bengt O. Lindgren. The oxidation takes...
concomitant conversion of the thioether to the sulfoxide or sulfone. LindgrenoxidationLindgren, Bengt O.; Nilsson, Torsten; Husebye, Steinar; Mikalsen, ØYvind;...
Lindegren, surname Astrid Lindgren Memorial Award Astrid Lindgren's World Lindgren Acres, Florida LindgrenoxidationLindgren Road Lindgren surname distribution...
Cecilia Margareta Lindgren is a Swedish geneticist. She is a Professor of Genomic Endocrinology & Metabolism in the Nuffield Department of Population Health...
through the oxidation of the cannabis plant's main psychoactive and intoxicating chemical, tetrahydrocannabinol (THC). This process of oxidation occurs via...
baggage issues have fallen to historic lows". Business Insider. Dwyer-Lindgren, Jeremy. "Boeing's new 737 MAX completes its maiden flight". USA Today...
is able to prevent the process of oxidation of LDL and the subsequent inflammatory processes seen after oxidation. Lipopolysaccharide, or LPS, is the...
on 23 October 2023. Retrieved 21 October 2023. "Hem - Astrid Lindgren - Astrid Lindgren". www.astridlindgren.com (in Swedish). Archived from the original...
Rituals". Povos Indígenas do Brasil. Retrieved 1 March 2017. Rivier, Laurent; Lindgren, Jan-Erik (1972-04-01). ""Ayahuasca," the South American hallucinogenic...
Technische Universität Darmstadt. Retrieved 12 October 2019. Wildes & Lindgren 1985, p. 19. "History". School of Electrical and Computer Engineering,...
family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (AA) and the essential fatty acid eicosapentaenoic...
associations and structural styles. This scheme, proposed by Waldemar Lindgren (1933) classified hydrothermal deposits as follows: Hypothermal — mineral...
PMID 15681804. S2CID 21762775. Oikonen M, Laippala P, Oksaranta O, Lilius EM, Lindgren S, et al. (2003). "Ambient air quality and occurrence of multiple sclerosis...
agents. Alprazolam triazolobenzophenone Rilmazafone GB 1517164 Karlsson B, Lindgren B, Millquist E, Sandberg M, Sellström A (April 1990). "On the use of diazepam...
on SAR Standards and the Basic Requirements for SAR Assessment" at ETS-Lindgren website (Archive.org link), April 2005 Example of a detailed SAR report...
Lindgren 1995, p. 310–311. Lindgren 1995, p. 328. Lindgren 1971, p. 117. Lagerlöf 1972, p. 296. Cutler 1969, p. 259. Lindgren 1996, p. 317. Lindgren 1996...
1988. Springer Science & Business Media. p. 717. ISBN 978-3-642-74034-3. Lindgren JE, Holmstedt B (1983). "Guide to the Analysis of Phencyclidine and its...
National Council for Science and the Environment. Giribet, G.; Okusu, A.; Lindgren, A.R.; Huff, S.W.; Schrödl, M.; Nishiguchi, M.K. (May 2006). "Evidence...
sources are extremely diverse, and range from the oxidation of ammonia by the Nitrosopumilales to the oxidation of hydrogen sulfide or elemental sulfur by species...
areas of research are in photocatalytic oxidation and photosensitized degradation. Photocatalytic oxidation uses a species that absorbs radiation and...
coactivator PGC-1α and stimulates hepatic gluconeogenesis, fatty acid oxidation, and ketogenesis. FGF21 also blocks somatic growth and sensitizes mice...
relatively brief period. The first known mass extinction was the Great Oxidation Event 2.4 billion years ago, which killed most of the planet's obligate...
Archived from the original on 11 November 2017. Retrieved 11 November 2017. Lindgren S (1993). Kliniska färdigheter: Informationsutbytet mellan patient och...
australis Cav". Scientia Pharmaceutica. 53: 169–170. Rivier, Laurent; Lindgren, Jan-Erik (1972). ""Ayahuasca," the South American Hallucinogenic Drink:...
PMC 4603435. PMID 25654408. Axelsson, L. T.; Chung, T. C.; Dobrogosz, W. J.; Lindgren, S. E. (April 1988). "Production of a Broad Spectrum Antimicrobial Substance...
1007/bf00408082. PMID 4559703. S2CID 9204044. Lindas, A.-C.; Karlsson, E. A.; Lindgren, M. T.; Ettema, T. J. G.; Bernander, R. (5 November 2008). "A unique cell...
Global Information