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Medical condition
Leukocyte-adhesion deficiency
Specialty
Immunology
Leukocyte adhesion deficiency (LAD) is a rare autosomal recessive disorder characterized by immunodeficiency resulting in recurrent infections.[1] LAD is currently divided into three subtypes: LAD1, LAD2, and the recently described LAD3, also known as LAD-1/variant. In LAD3, the immune defects are supplemented by a Glanzmann thrombasthenia-like bleeding tendency.[2][3]
^Robert P; Canault M; Farnarier C; Nurden A; Grosdidier C; Barlogis V; … Alessi MC (2011). "A novel leukocyte adhesion deficiency III variant: kindlin-3 deficiency results in integrin- and nonintegrin-related defects in different steps of leukocyte adhesion". Journal of Immunology. 186 (9): 5273–83. doi:10.4049/jimmunol.1003141. PMID 21441448.
^Abbas AK, Lichtman AH, Pillai S (2012). Cellular and molecular immunology (7th ed.). Philadelphia: Elsevier/Saunders. ISBN 978-1-4377-1528-6.
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Leukocyteadhesiondeficiency (LAD) is a rare autosomal recessive disorder characterized by immunodeficiency resulting in recurrent infections. LAD is...
Leukocyte extravasation (also commonly known as leukocyteadhesion cascade or diapedesis – the passage of cells through the intact vessel wall) is the...
caused by an inability to express specific adhesion molecules. An example is leukocyteadhesiondeficiency-I (LAD-I), where expression of the β2 integrin...
(X-linked recessive), or autosomal recessive disorder, such as Leukocyteadhesiondeficiency-2 (LAD2). A unilateral single palmar crease was also reported...
syndrome, leukocyteadhesiondeficiency, cancer and other acquired human diseases. They are essential in the organisation of focal adhesions that mediate...
splenectomy. Primary neutrophilia can additionally be a result of leukocyteadhesiondeficiency. A "left shift" refers to the presence of increased proportions...
branch Left axis deviation, a condition in electrocardiography Leukocyteadhesiondeficiency Locally advanced disease, a stage in cancer staging Lymphadenopathy...
be homozygous for a mutation in the gene that caused bovine leukocyteadhesiondeficiency. This mutation was found at a high frequency in Holstein populations...
CD11a has been shown to interact with ICAM-1. CD11c integrin leukocyteadhesiondeficiency Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000005844...
Medicine Advanced Therapy Designation for RP-L201 Gene Therapy for LeukocyteAdhesionDeficiency-I". www.businesswire.com. 2021-03-09. Retrieved 2021-07-02....
on endothelial cells, which mediate the adhesion and further slow leukocytes down. These weakly bound leukocytes are free to detach if not activated by...
Neutrophils (also known as neutrocytes, heterophils or polymorphonuclear leukocytes) are a type of white blood cell. More specifically, they form the most...
group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyteadhesiondeficiency, type II. ENSG00000278243 GRCh38:...
First, platelets attach to substances outside the interrupted endothelium: adhesion. Second, they change shape, turn on receptors and secrete chemical messengers:...
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