DKK2 information

DKK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JTK
Identifiers
Aliases	DKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2
External IDs	OMIM: 605415 MGI: 1890663 HomoloGene: 8681 GeneCards: DKK2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	107,283,806 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	131,886,065 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; hair follicle; ; thoracic diaphragm; ; right lung; ; right coronary artery; ; lower lobe of lung; ; tibial nerve; ; visceral pleura; ; upper lobe of lung; ; upper lobe of left lung;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; iris; ; glomerulus; ; belly cord; ; conjunctival fornix; ; saccule; ; cornea; ; dermis; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	co-receptor binding; receptor antagonist activity;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of canonical Wnt signaling pathway; multicellular organism development; negative regulation of Wnt signaling pathway; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; extracellular negative regulation of signal transduction; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	27123
	56811
	ENSG00000155011
	ENSMUSG00000028031
	Q9UBU2
	Q9QYZ8
	NM_014421
	NM_020265
	NP_055236
	NP_064661
	Wikidata
View/Edit Human	View/Edit Mouse

Dickkopf-related protein 2 is a protein in the Dickkopf family that in humans is encoded by the DKK2 gene.^[5]^[6]

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.

It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155011 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028031 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (October 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
^ ^a ^b "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155011 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028031 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10570958-5] Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (October 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.

[entrez-6] "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)".

DKK2 information

and 11 Related for: DKK2 information

DKK2

Dickkopf

List of distinct cell types in the adult human body

Chromosome 4

Nephronectin

Neuron derived neurotrophic factor

METTL14

INTS12

Complement factor I

LRIT3

SLC9B2