LGR5 information

LGR5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BSR, 4BSS, 4BST, 4BSU, 4KNG, 4UFR, 4UFS
Identifiers
Aliases	LGR5, FEX, GPR49, GPR67, GRP49, HG38, leucine-rich repeat containing G protein-coupled receptor 5, leucine rich repeat containing G protein-coupled receptor 5
External IDs	OMIM: 606667 MGI: 1341817 HomoloGene: 20807 GeneCards: LGR5
Gene location (Human)
Chr.	Chromosome 12 (human)
End	71,586,310 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	115,423,685 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; gastrocnemius muscle; ; placenta; ; thoracic diaphragm; ; spinal ganglia; ; vastus lateralis muscle; ; biceps brachii; ; right uterine tube; ; corpus callosum; ; deltoid muscle;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; lip; ; olfactory bulb; ; calvaria; ; anterior horn of spinal cord; ; adrenal gland; ; Paneth cell; ; stellate reticulum; ; skin of abdomen; ; skin of back;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity; protein-hormone receptor activity; G protein-coupled peptide receptor activity;
Cellular component	integral component of membrane; plasma membrane; Golgi apparatus; integral component of plasma membrane; trans-Golgi network membrane; membrane;
Biological process	positive regulation of canonical Wnt signaling pathway; hair follicle development; inner ear development; G protein-coupled receptor signaling pathway; epithelial cell proliferation involved in renal tubule morphogenesis; regulation of cell population proliferation; oocyte differentiation; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; hormone-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8549
	14160
	ENSG00000139292
	ENSMUSG00000020140
	O75473
	Q9Z1P4
	NM_001277226; NM_001277227; NM_003667
	NM_010195
	NP_001264155; NP_001264156; NP_003658
	NP_034325
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G-protein coupled receptor 67 (GPR67) is a protein that in humans is encoded by the LGR5 gene.^[5]^[6] It is a member of GPCR class A receptor proteins. R-spondin proteins are the biological ligands of LGR5. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139292 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020140 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McDonald T, Wang R, Bailey W, Xie G, Chen F, Caskey CT, Liu Q (Jul 1998). "Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily". Biochem Biophys Res Commun. 247 (2): 266–70. doi:10.1006/bbrc.1998.8774. PMID 9642114.
^ McClanahan T, Koseoglu S, Smith K, Grein J, Gustafson E, Black S, Kirschmeier P, Samatar AA (April 2006). "Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors". Cancer Biol. Ther. 5 (4): 419–26. doi:10.4161/cbt.5.4.2521. PMID 16575208.
^ Hsu SY, Liang SG, Hsueh AJ (December 1998). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/mend.12.12.0211. PMID 9849958.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139292 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020140 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9642114-5] McDonald T, Wang R, Bailey W, Xie G, Chen F, Caskey CT, Liu Q (Jul 1998). "Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily". Biochem Biophys Res Commun. 247 (2): 266–70. doi:10.1006/bbrc.1998.8774. PMID 9642114.

[McClanahan_2006-6] McClanahan T, Koseoglu S, Smith K, Grein J, Gustafson E, Black S, Kirschmeier P, Samatar AA (April 2006). "Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors". Cancer Biol. Ther. 5 (4): 419–26. doi:10.4161/cbt.5.4.2521. PMID 16575208.

[Hsu_1998-7] Hsu SY, Liang SG, Hsueh AJ (December 1998). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/mend.12.12.0211. PMID 9849958.

LGR5 information

and 19 Related for: LGR5 information

LGR5

Organoid

Hair follicle

Hans Clevers

List of intestinal stem cell marker genes

CHIR99021

List of distinct cell types in the adult human body

Meritxell Huch

List of intestinal epithelial differentiation genes

Renal stem cell

Cancer stem cell

Stem cell marker

LGR6

KLF4

Owen Sansom

CDX1

NEDD4

Mendel Lectures

Institute of Molecular Biotechnology