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Representative phase-contrast image of LNCaP cells. Scale bars represent 100 μm.Properties of common PCa cell lines
LNCaP cells are a cell line of human cells commonly used in the field of oncology. LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old caucasian male in 1977. They are adherent epithelial cells growing in aggregates and as single cells.[1]
One major obstacle to conducting the most clinically relevant prostate cancer (PCa) research has been the lack of cell lines that closely mimic human disease progression.[2] Two hallmarks of metastatic human prostate cancer include the shift of aggressive PCa from androgen-sensitivity to an Androgen Insensitive (AI) state, and the propensity of PCa to metastasize to bone.[3] Although the generation of AI cell lines has been quite successful as demonstrated in the “classic” cell lines DU145 and PC3, the behavior of these cells in bone does not fully mimic clinical human disease. It is well established that human PCa bone metastasis form osteoblastic lesions rather than osteolytic lesions seen in other cancers like breast cancer.[4][5] Similarly, PC-3 and DU145 cells form osteolytic tumors. To develop an AI-PCa cell model that more closely mimics clinical disease, LNCaP sublines have been generated to provide the most clinically relevant tissue culture tools to date.
^Horoszewicz JS, Leong SS, Kawinski E, Karr JP, Rosenthal H, Chu TM, Mirand EA, Murphy GP (April 1983). "LNCaP model of human prostatic carcinoma". Cancer Res. 43 (4): 1809–18. PMID 6831420.
^Cite error: The named reference pmid8168083 was invoked but never defined (see the help page).
^Fanelli, Alex (2016). "LNCaP Cell Line: human prostate adenocarcinoma cell line". Retrieved 3 December 2017.
^Koeneman KS, Yeung F, Chung LW (June 1999). "Osteomimetic properties of prostate cancer cells: a hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment". Prostate. 39 (4): 246–61. doi:10.1002/(SICI)1097-0045(19990601)39:4<246::AID-PROS5>3.0.CO;2-U. PMID 10344214.
^Lin DL, Tarnowski CP, Zhang J, Dai J, Rohn E, Patel AH, Morris MD, Keller ET (May 2001). "Bone metastatic LNCaP-derivative C4-2B prostate cancer cell line mineralizes in vitro" (PDF). Prostate. 47 (3): 212–21. doi:10.1002/pros.1065. hdl:2027.42/34759. PMID 11351351. S2CID 31076493.
LNCaP cells are a cell line of human cells commonly used in the field of oncology. LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells...
potential, and to LNCaP cells, which have low metastatic potential.[citation needed] Comparisons of the protein expression of PC3, LNCaP, and other cells...
inhibits the androgen induced-proliferation of prostate cancer cell line LNCaP through suppression of AR transcription activity". Tianjin Journal of Traditional...
constituent of Serenoa or Saw palmetto, and appears to have activity against LNCaP prostate-cancer cells. Cetyl myristoleate Myristoleic acid Archived 2012-03-17...
AR than DHT, the endogenous ligand of the AR in the prostate gland. When LNCaP cells (a prostate cancer cell line) engineered to express elevated levels...
androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP". The Journal of Biological Chemistry. 272 (28): 17485–94. doi:10.1074/jbc...
on IN/IRS-1/MAPK and Wnt/β-catenin cascades, causing HCC transformation. LNCaP prostate cancer cells increase cell adhesion and diminish cell motility...
DU145 (DU-145) is a human prostate cancer cell line. DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic...
Jones SJ (September 2006). "Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach". BMC Genomics. 7:...
accomplished with RNA from a prostate tumor cell line, LNCaP. PSMA was first detected in the LNCaP cell line using the murine monoclonal antibody 7E11-C5...
cells.) Zhang et al. first assessed the level of survivin expression of LNCaP (an androgen-dependent prostate cancer cell line that expresses intact androgen...
used, namely the classic lines DU145, PC-3, and LNCaP, as well as more recent cell lines 22Rv1, LAPC-4, VCaP, and MDA-PCa-2a and −2b. Research requiring more...
comparison of the effects of bicalutamide treatment and AR knockdown by siRNA in LNCaP cells, using a limited gene array, demonstrates that the two treatments...
TRPM8 protein in the ER and plasma membrane of the androgen-responsive LNCaP cell line. TRPM8 was expressed in androgen-insensitive cells, but it was...
transformed by being bound to trastuzumab to attach to androgen-sensitive LNCaP and castration-resistant C4-2 human prostate cancer cell lines. These two...
(November 2004). "Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells". Cancer Res. 64 (21): 7686–9. doi:10.1158/0008-5472...
inhibitor/acyl-CoA-binding protein in the human prostatic adenocarcinoma cell line LNCaP". Mol. Cell. Endocrinol. 104 (2): 153–162. doi:10.1016/0303-7207(94)90118-X...
nanoparticle to move an antitumor drug, Cisplatin, within a prostate cancer cell (LNCaP/PC3) population. Use of platinum in drug delivery hinges on its ability...
"Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells". Oncogene. 19 (15): 1924–1932. doi:10.1038/sj.onc...
effectively. Two of the extracts were tested in human xenograft C4-2/Relapsed LNCaP human xenograft model and found effective in inhibiting growth of tumors...
diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells". Endocrinology. 138 (7): 2998–3005. doi:10.1210/endo.138.7.5226....
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