Discovery and development of antiandrogens information
The first antiandrogen was discovered in the 1960s. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases.[1][2][3] Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and salivary duct carcinoma[4] and that antiandrogens can potentially be used to treat it.[5][6]
As of 2010[update] antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens (NSAAs) may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.[2]
^Denmeade SR, Isaacs JT (May 2002). "A history of prostate cancer treatment". Nature Reviews. Cancer. 2 (5): 389–96. doi:10.1038/nrc801. PMC 4124639. PMID 12044015.
^ abCite error: The named reference Therapeutic target was invoked but never defined (see the help page).
^Cite error: The named reference Antiandrogens was invoked but never defined (see the help page).
^Williams L, Thompson LD, Seethala RR, Weinreb I, Assaad AM, Tuluc M, et al. (May 2015). "Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression". The American Journal of Surgical Pathology. 39 (5): 705–13. doi:10.1097/pas.0000000000000413. PMID 25871467. S2CID 24737257.
^Gucalp A, Traina TA (Jan–Feb 2010). "Triple-negative breast cancer: role of the androgen receptor". Cancer Journal. 16 (1): 62–5. doi:10.1097/PPO.0b013e3181ce4ae1. PMID 20164692. S2CID 6922842.
^Urban D, Rischin D, Angel C, D'Costa I, Solomon B (March 2015). "Abiraterone in metastatic salivary duct carcinoma". Journal of the National Comprehensive Cancer Network. 13 (3): 288–90. doi:10.6004/jnccn.2015.0040. PMID 25736005.
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from the addition of an antiandrogen, as antiandrogens can reduce or eliminate such symptoms. Steroidal antiandrogens are antiandrogens that resemble steroid...
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the treatment of hidradenitis suppurativa in girls and women. Finasteride and other antiandrogens might be useful in the treatment of obsessive–compulsive...
treatment of androgen-dependent skin and hair conditions, and hence can significantly augment the effectiveness ofantiandrogens in the treatment of such conditions...
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anddevelopment offices in Princeton, New Jersey, and in Basel, Switzerland. The Swiss-based Hengrui Europe Therapeutics AG also hosts the discovery research...
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