Apoptosis in DU145 prostate cancer cells, induced by etoposide.
DU145 (DU-145) is a human prostate cancer cell line.[1] DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research.[1]
The DU145 cell line was derived from a central nervous system metastasis, of primary prostate adenocarcinoma origin, removed during a parieto-occipital craniotomy of a 69-year-old, White, male.[2][3] DU145 are not hormone-sensitive and do not express prostate-specific antigen (PSA). DU145 cells have moderate metastatic potential compared to PC3 cells, which have high metastatic potential.[4]
^ abAlimirah, Fatouma; Chen, Jianming; Basrawala, Zane; Xin, Hong; Choubey, Divaker (2006-04-17). "DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation". FEBS Letters. 580 (9): 2294–2300. doi:10.1016/j.febslet.2006.03.041. PMID 16580667. S2CID 21777101.
^Stone, Kenneth R.; Mickey, Don D.; Wunderli, Heidi; Mickey, George H.; Paulson, David F. (1978-03-15). "Isolation of a human prostate carcinoma cell line (DU 145)". International Journal of Cancer. 21 (3): 274–281. doi:10.1002/ijc.2910210305. PMID 631930. S2CID 26978561.
^Pulukuri, Sai MuraliKrishna; Gondi, Christopher S.; Lakka, Sajani S.; Jutla, Aman; Estes, Norman; Gujrati, Meena; Rao, Jasti S. (2005-10-28). "RNA Interference-directed Knockdown of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Inhibits Prostate Cancer Cell Invasion, Survival, and Tumorigenicity in Vivo*". Journal of Biological Chemistry. 280 (43): 36529–36540. doi:10.1074/jbc.M503111200. ISSN 0021-9258. PMC 1351057. PMID 16127174.
DU145 (DU-145) is a human prostate cancer cell line. DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic...
[citation needed] PC3 cells have high metastatic potential compared to DU145 cells, which have a moderate metastatic potential, and to LNCaP cells, which...
Apoptosis An etoposide-treated DU145 prostate cancer cell exploding into a cascade of apoptotic bodies. The sub images were extracted from a 61-hour time-lapse...
use include:[citation needed] bioassays; using cancerous cell lines, like DU145 for prostate cancer, in drug testing of anticancer agents; measurements...
prostate immortalized cell lines are widely used, namely the classic lines DU145, PC-3, and LNCaP, as well as more recent cell lines 22Rv1, LAPC-4, VCaP...
antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States...
lines has been quite successful as demonstrated in the “classic” cell lines DU145 and PC3, the behavior of these cells in bone does not fully mimic clinical...
K. Tyagi et al., Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G(2)-M arrest, and apoptosis...
lysis and formation of a viral plaque.[citation needed] Human cell lines DU145 (prostate cancer) H295R (adrenocortical cancer) HeLa (cervical cancer) KBM-7...
lymphoma PC-3 human prostate carcinoma derived from metastatic site in bone DU145 human prostate carcinoma derived from metastatic site in brain 4T1 mouse...
suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells". Biochemical and Biophysical Research Communications. 248 (2): 361–7...
"Expression of prostasome-like granules by the prostate cancer cell lines PC3, Du145 and LnCaP grown in monolayer". Upsala Journal of Medical Sciences. 104 (3):...
cell lines U937 and HL-60 The prostate cancer cell lines PC, LNCaP and DU145 The pancreatic cancer cell line Panc-1 The ovarian cancer cell line S-2[dubious...
cell lines, LNCaP (androgen-dependent) and DU145 (androgen-independent), show SLC46A3 expression in DU145 to be about 5 times as high as in LNCaP for...
in primary prostate tumors compared with normal prostate specimens after DU145 cells which express retinoid receptors were cultured in the presence of...
verified against prostate cancer induced with N-methyl-nitrosourea and in the DU145 cell line. "Chuquiraga spinosa". The Plant List. Retrieved 20 November 2014...
antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States...
Bertino JR. Darinaparsin inhibits prostate tumor–initiating cells and Du145 xenografts and is an inhibitor of Hedgehog signaling. Molecular cancer therapeutics...
androgen-independent and androgen receptor-negative cell lines (PC-3MM2 and DU145) have high expression levels of SMAD3. Analysis of the relation between...
docosahexaenoic and eicosapentaenoic acids to stimulate the proliferation of human DU145 and PC-3 prostate cancer cells (this result suggests that activated FFAR1...
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