cysteine-type endopeptidase inhibitor activity involved in apoptotic process
protein binding
identical protein binding
protein heterodimerization activity
enzyme binding
microtubule binding
zinc ion binding
cysteine-type endopeptidase inhibitor activity
Cellular component
cytosol
spindle
chromosome
nucleoplasm
chromosome passenger complex
nuclear chromosome
interphase microtubule organizing center
spindle microtubule
centriole
cytoplasmic microtubule
cytoskeleton
microtubule
kinetochore
midbody
cytoplasm
chromosome, centromeric region
nucleus
Biological process
negative regulation of peptidase activity
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of transcription, DNA-templated
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
establishment of chromosome localization
chromosome segregation
positive regulation of mitotic cell cycle
positive regulation of exit from mitosis
transcription, DNA-templated
cell division
protein phosphorylation
mitotic spindle assembly
regulation of signal transduction
G2/M transition of mitotic cell cycle
positive regulation of cell population proliferation
protein-containing complex localization
cell cycle
negative regulation of transcription, DNA-templated
apoptotic process
regulation of apoptotic process
negative regulation of apoptotic process
regulation of mitotic cell cycle
mitotic cell cycle
sensory perception of sound
mitotic cytokinesis
mitotic spindle assembly checkpoint signaling
cytokine-mediated signaling pathway
protein ubiquitination
negative regulation of endopeptidase activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
332
11799
Ensembl
ENSG00000089685
ENSMUSG00000017716
UniProt
O15392
O70201
RefSeq (mRNA)
NM_001012270 NM_001012271 NM_001168
NM_001012272 NM_001012273 NM_009689
RefSeq (protein)
NP_001012270 NP_001012271 NP_001159
NP_001012273 NP_033819
Location (UCSC)
Chr 17: 78.21 – 78.23 Mb
Chr 11: 117.74 – 117.75 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.[5][6]
Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.[7] These data suggest survivin might provide a new target for cancer therapy that would discriminate between transformed and normal cells. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that Survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. The molecular mechanisms of survivin regulation are still not well understood, but regulation of survivin seems to be linked to the p53 protein. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000089685 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000017716 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Altieri DC (February 1994). "Molecular cloning of effector cell protease receptor-1, a novel cell surface receptor for the protease factor Xa". J. Biol. Chem. 269 (5): 3139–42. doi:10.1016/S0021-9258(17)41838-2. PMID 8106347.
^Altieri DC (November 1994). "Splicing of effector cell protease receptor-1 mRNA is modulated by an unusual retained intron". Biochemistry. 33 (46): 13848–55. doi:10.1021/bi00250a039. PMID 7947793.
^Sah NK, Khan Z, Khan GJ, Bisen PS (December 2006). "Structural, functional and therapeutic biology of survivin". Cancer Lett. 244 (2): 164–71. doi:10.1016/j.canlet.2006.03.007. PMID 16621243.
^Olie RA, Simões-Wüst AP, Baumann B, Leech SH, Fabbro D, Stahel RA, Zangemeister-Wittke U (June 2000). "A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy". Cancer Res. 60 (11): 2805–9. PMID 10850418.
Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin...
to survivin mRNA and inhibits its expression in tumor tissue. It being investigated for a number of different cancers. It is targeted at survivin which...
of the album was released on 7 February 2022. It includes the single "Survivin'” from their 2020 Goosebumps EP. Bastille toured the UK and Europe starting...
and Silent Bob Strike Back Justice Thirteen Ghosts Kathy Kriticos 2002 Survivin' the Island Office worker Uncredited role 2003 Love Actually Harriet 2004...
Aurora B and Aurora C. It acts in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N-terminal...
rapid proliferation of tumour cells, survivin is more expressed during the presence of cancer. The level of survivin correlates to how resistance to chemotherapy...
levels of DNA damage, ATG5 can translocate to the nucleus and interact with survivin. ATG5 is known to be regulated via various stress induced transcription...
Caspase 3 has been shown to interact with: CASP8 NMT2 CFLAR DCC GroEL HCLS1 Survivin TRAF3 XIAP NFE2L2 Caspase-3 has been found to be necessary for normal brain...
focusing on mitochondrial exploitation in cancer, he is the discoverer of the survivin gene, a fundamental regulator of cell division and cell survival universally...
cancers. The antigens included peptides from HER2, telomerase (TERT), survivin (BIRC5), and Wilms’ tumor 1 (WT1). Several trials also used “personalized”...
is a human gene. This locus represents an antisense transcript of the survivin locus. This record was withdrawn in collaboration with HGNC. It was defined...
Environmental Remediation Prashant Kesharwani (India) in Biological Sciences For: Survivin targeted siRNA using cancer selective nanoparticles for triple negative...
maintain a high level of PKB activity and expression of Bcl-2, Bcl-XL and survivin. OX40L binds to OX40 receptors on T-cells, preventing them from dying and...
Antiapoptotic proteins, such as clusterin and survivin, are often expressed in cancer cells. Clusterin and survivin-targeting siRNAs were used to reduce the...
subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin". Oncol Rep. 29 (4): 1333–42. doi:10.3892/or.2013.2242. PMID 23338618....
Another key aspect of cancer is inhibition of cell death or apoptosis. Survivin, a member of the inhibitor of apoptosis (IAP) family, is localized in pools...
complex plays a critical role in the expression of the survival signal survivin. Survivin is necessary for proper creation of the mitotic spindle which strongly...
by astral microtubules. Aurora B complexes with three other proteins, Survivin, Borealin and INCENP. Each of the four components of the complex is required...
IAPs were discovered which included XIAP, cIAP1 , C-IAP2, NAIP, Livin and Survivin. The best characterized IAP is XIAP, which binds caspase-9, caspase-3 and...
Singellista Chart, but peaked at number 16 on the Swedish Heatseeker Chart. "Survivin'" did not enter the UK Singles Chart but peaked at number 76 on the UK...
include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6. BIR domains belong to the zinc-finger domain family and characteristically...
bipolar mitotic spindle. CDCA8 has been shown to interact with INCENP, Survivin and Aurora B kinase. GRCh38: Ensembl release 89: ENSG00000134690 – Ensembl...
Global Information
