Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.[5]
Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000111057 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023043 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: KRT18 keratin 18".
^W. Jeffrey Allard, Jeri Matera, M. Craig Miller, et al. (October 2004). "Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases" (PDF). Clinical Cancer Research. 10 (20): 6897–6904. doi:10.1158/1078-0432.CCR-04-0378. PMID 15501967.
Keratin18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate...
Keratin (/ˈkɛrətɪn/) is one of a family of structural fibrous proteins also known as scleroproteins. Alpha-keratin (α-keratin) is a type of keratin found...
is encoded by the KRT19 gene. Keratin 19 is a type I keratin. Keratin 19 is a member of the keratin family. The keratins are intermediate filament proteins...
Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene....
Keratin 6A is one of the 27 different type II keratins expressed in humans. Keratin 6A was the first type II keratin sequence determined. Analysis of the...
Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene. Keratin...
Keratin, type II cytoskeletal 7 also known as cytokeratin-7 (CK-7) or keratin-7 (K7) or sarcolectin (SCL) is a protein that in humans is encoded by the...
Keratin 14 is a member of the type I keratin family of intermediate filament proteins. Keratin 14 was the first type I keratin sequence determined. Keratin...
and binds to Keratin 10, a Type I keratin, to form a coiled coil heterotypic keratin chain. Keratin 1 and Keratin 10 are specifically expressed in the...
Keratin 2A also known as keratin 2E or keratin 2 is a protein that in humans is encoded by the KRT2A gene. Keratin 2A is a type II cytokeratin. It is found...
K18 may refer to: K-18 (Kansas highway) Keratin18 Symphony No. 3 (Mozart), once attributed to Wolfgang Amadeus Mozart This disambiguation page lists articles...
first detectable after 18-19 days of gestation. Quaroni, A.; Calnek, D.; Quaroni, E.; Chandler, J. S. (25 June 1991). "Keratin expression in rat intestinal...
Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene. It dimerizes with keratin 14 and forms the intermediate...
Keratin 16 is a protein that in humans is encoded by the KRT16 gene. Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial...
Keratin 12 is a protein that in humans is encoded by the KRT12 gene. Keratin 12 is keratin found expressed in corneal epithelia. Mutations in the gene...
Type II keratins (or Type II cytokeratins) constitutes the Type II intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present...
Keratin 15 is a protein that in humans is encoded by the KRT15 gene. It has also been referred to as cytokeratin 15, K1CO and KRTB. Keratin 15 is a type...
Keratin 3 also known as cytokeratin 3 is a protein that in humans is encoded by the KRT3 gene. Keratin 3 is a type II cytokeratin. It is specifically found...
Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene. Keratin 13 is a type I cytokeratin, it is paired with keratin...
Keratin 9 is a protein that in humans is encoded by the KRT9 gene. Keratin 9 is a type I cytokeratin. It is found only in the terminally differentiated...
Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue. They are an important component of intermediate filaments...
Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene. Keratin 4...
the body. Keratin is a structural protein located at the hard surfaces in many vertebrates. Keratin has two forms, α-keratin and β-keratin, that are found...
Type I keratins (or Type I cytokeratins) are cytokeratins that constitute the Type I intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton...
structures. The epithelial component is positive for keratin (keratin AE1/AE3, keratin18, keratin 7) c-KIT and CD56. The mesenchymal component is positive...
Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene. Keratin 17 is a type I cytokeratin. It is found in nail beds...
VCaP, LAPC4 have high expression of Keratin 5, a basal marker, as well as the luminal markers Keratin 8 and Keratin18. LAPC4 also expresses mutated P53...
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