Global InformationLAPC4 information
LAPC4 cells are a cell line of human prostate cancer commonly used in the field of oncology. The tissue was harvested from the lymph node metastasis of a male patient with hormone refractory prostate cancer which was then xenografted into SCID mice and later harvested and plated on tissue culture dishes, where it can be propagated as an immortalized prostate cancer cell line.[1][2][3]
- ^ Klein, KA; Reiter, RE; Redula, J; Moradi, H; Zhu, XL; Brothman, AR; Lamb, DJ; Marcelli, M; Belldegrun, A; Witte, ON; Sawyers, CL (April 1997). "Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice". Nature Medicine. 3 (4): 402–8. doi:10.1038/nm0497-402. PMID 9095173. S2CID 21273888.
- ^ Russell, Pamela J.; Kingsley, Elizabeth A. (2003). "Chapter 2: Human Prostate Cancer Cell Lines" (PDF). In Russell, Pamela J.; Jackson, Paul; Kingsley, Elizabeth A. (eds.). Prostate cancer methods and protocols. Totowa, N.J.: Humana Press. pp. 21–39. ISBN 978-1-59259-372-9.
- ^ Garcia, RR; Masoodi, KZ; Pascal, LE; Nelson, JB; Wang, Z (2014). "Growth of LAPC4 prostate cancer xenograft tumor is insensitive to 5α-reductase inhibitor dutasteride". American Journal of Clinical and Experimental Urology. 2 (1): 82–91. PMC 4219295. PMID 25374909.