KLF4 information

KLF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WBS, 2WBU, 4M9E
Identifiers
Aliases	KLF4, EZF, GKLF, Kruppel-like factor 4 (gut), Kruppel like factor 4
External IDs	OMIM: 602253 MGI: 1342287 HomoloGene: 3123 GeneCards: KLF4
Gene location (Human)
Chr.	Chromosome 9 (human)
End	107,490,482 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	55,532,466 bp
RNA expression pattern
	Top expressed in
	human penis; ; synovial joint; ; skin of abdomen; ; vulva; ; jejunal mucosa; ; nipple; ; gastric mucosa; ; urethra; ; gums; ; oral cavity;
	Top expressed in
	epithelium of stomach; ; mucous cell of stomach; ; conjunctival fornix; ; left colon; ; pyloric antrum; ; intestinal villus; ; belly cord; ; cervix; ; stria vascularis; ; skin of abdomen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; beta-catenin binding; phosphatidylinositol 3-kinase regulator activity; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; cis-regulatory region sequence-specific DNA binding; metal ion binding; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; protein binding; nucleic acid binding; double-stranded DNA binding; promoter-specific chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coregulator binding; histone deacetylase binding;
Cellular component	cytoplasm; transcription regulator complex; nucleoplasm; chromatin; nucleus;
Biological process	negative regulation of chemokine (C-X-C motif) ligand 2 production; epidermal cell differentiation; cellular response to retinoic acid; negative regulation of protein kinase B signaling; negative regulation of muscle hyperplasia; negative regulation of smooth muscle cell proliferation; positive regulation of protein metabolic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of axon regeneration; cellular response to peptide; regulation of transcription, DNA-templated; positive regulation of hemoglobin biosynthetic process; response to retinoic acid; somatic stem cell population maintenance; cellular response to laminar fluid shear stress; regulation of transcription by RNA polymerase II; cell differentiation; epidermis morphogenesis; positive regulation of nitric oxide biosynthetic process; cellular response to growth factor stimulus; cellular response to organic cyclic compound; post-embryonic hemopoiesis; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; response to organic substance; negative regulation of gene expression; negative regulation of response to cytokine stimulus; transcription, DNA-templated; negative regulation of DNA-binding transcription factor activity; negative regulation of phosphatidylinositol 3-kinase signaling; stem cell population maintenance; negative regulation of cell migration involved in sprouting angiogenesis; positive regulation of gene expression; negative regulation of cell migration; regulation of cell population proliferation; post-embryonic camera-type eye development; regulation of phosphatidylinositol 3-kinase activity; positive regulation of telomerase activity; canonical Wnt signaling pathway; negative regulation of ERK1 and ERK2 cascade; regulation of cell differentiation; mesodermal cell fate determination; negative regulation of heterotypic cell-cell adhesion; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; cellular response to cycloheximide; negative regulation of inflammatory response; fat cell differentiation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; cellular response to hydrogen peroxide; negative regulation of leukocyte adhesion to arterial endothelial cell; positive regulation of core promoter binding; cellular response to leukemia inhibitory factor; negative regulation of angiogenesis; pri-miRNA transcription by RNA polymerase II; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of transcription, DNA-templated; positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9314
	16600
	ENSG00000136826
	ENSMUSG00000003032
	O43474
	Q60793
	NM_001314052; NM_004235
	NM_010637
	NP_001300981; NP_004226
	NP_034767
	Wikidata
View/Edit Human	View/Edit Mouse

Kruppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors.^[5]^[6]^[7] KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer.^[8] It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2.^[6] It has two nuclear localization sequences that signals it to localize to the nucleus.^[9] In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).

In humans, the protein is 513 amino acids, with a predicted molecular weight of approximately 55kDa, and is encoded by the KLF4 gene.^[10] The KLF4 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.^[11] KLF4 was first identified in 1996.^[12]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136826 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003032 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Black AR, Black JD, Azizkhan-Clifford J (August 2001). "Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer". Journal of Cellular Physiology. 188 (2): 143–60. doi:10.1002/jcp.1111. PMID 11424081. S2CID 39150180.
^ ^a ^b Dang DT, Pevsner J, Yang VW (November 2000). "The biology of the mammalian Krüppel-like family of transcription factors". The International Journal of Biochemistry & Cell Biology. 32 (11–12): 1103–21. doi:10.1016/s1357-2725(00)00059-5. PMC 2754176. PMID 11137451.
^ Kaczynski J, Cook T, Urrutia R (2003). "Sp1- and Krüppel-like transcription factors". Genome Biology. 4 (2): 206. doi:10.1186/gb-2003-4-2-206. PMC 151296. PMID 12620113.
^ El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW (August 2013). "Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts". Molecular Cancer. 12: 89. doi:10.1186/1476-4598-12-89. PMC 3750599. PMID 23919723.
^ Shields JM, Yang VW (July 1997). "Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins". The Journal of Biological Chemistry. 272 (29): 18504–7. doi:10.1074/jbc.272.29.18504. PMC 2268085. PMID 9218496.
^ "Entrez Gene: KLF4 Kruppel-like factor 4 (gut)".
^ "Kruppel-like factor 4".
^ Shields JM, Christy RJ, Yang VW (August 1996). "Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest". The Journal of Biological Chemistry. 271 (33): 20009–17. doi:10.1074/jbc.271.33.20009. PMC 2330254. PMID 8702718.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136826 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003032 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Black AR, Black JD, Azizkhan-Clifford J (August 2001). "Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer". Journal of Cellular Physiology. 188 (2): 143–60. doi:10.1002/jcp.1111. PMID 11424081. S2CID 39150180.

[pmid11137451-6] Dang DT, Pevsner J, Yang VW (November 2000). "The biology of the mammalian Krüppel-like family of transcription factors". The International Journal of Biochemistry & Cell Biology. 32 (11–12): 1103–21. doi:10.1016/s1357-2725(00)00059-5. PMC 2754176. PMID 11137451.

[7] Kaczynski J, Cook T, Urrutia R (2003). "Sp1- and Krüppel-like transcription factors". Genome Biology. 4 (2): 206. doi:10.1186/gb-2003-4-2-206. PMC 151296. PMID 12620113.

[8] El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW (August 2013). "Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts". Molecular Cancer. 12: 89. doi:10.1186/1476-4598-12-89. PMC 3750599. PMID 23919723.

[9] Shields JM, Yang VW (July 1997). "Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins". The Journal of Biological Chemistry. 272 (29): 18504–7. doi:10.1074/jbc.272.29.18504. PMC 2268085. PMID 9218496.

[10] "Entrez Gene: KLF4 Kruppel-like factor 4 (gut)".

[11] "Kruppel-like factor 4".

[pmid8702718-12] Shields JM, Christy RJ, Yang VW (August 1996). "Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest". The Journal of Biological Chemistry. 271 (33): 20009–17. doi:10.1074/jbc.271.33.20009. PMC 2330254. PMID 8702718.

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