STAU1 information

STAU1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DKK
Identifiers
Aliases	STAU1, PPP1R150, STAU, staufen double-stranded RNA binding protein 1
External IDs	OMIM: 601716; MGI: 1338864; HomoloGene: 3384; GeneCards: STAU1; OMA:STAU1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	49,188,367 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	166,838,219 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; secondary oocyte; ; amniotic fluid; ; parietal pleura; ; pancreatic ductal cell; ; visceral pleura; ; endothelial cell; ; germinal epithelium; ; palpebral conjunctiva; ; glomerulus;
	Top expressed in
	cumulus cell; ; molar; ; secondary oocyte; ; neural tube; ; maxillary prominence; ; ganglionic eminence; ; lip; ; external carotid artery; ; internal carotid artery; ; proximal tubule;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 1 binding; protein binding; double-stranded RNA binding; RNA binding;
Cellular component	cytoplasm; cell body; rough endoplasmic reticulum; membrane; plasma membrane; microtubule associated complex; neuronal cell body; dendrite; endoplasmic reticulum; cytoplasmic ribonucleoprotein granule; neuron projection; cytoplasmic stress granule; extracellular exosome; cytosol; glutamatergic synapse;
Biological process	positive regulation of long-term synaptic potentiation; positive regulation by virus of viral protein levels in host cell; cellular response to oxidative stress; positive regulation of viral genome replication; modulation of chemical synaptic transmission; modification of postsynaptic structure; viral process;
	Sources:Amigo / QuickGO
Orthologs
	6780
	20853
	ENSG00000124214
	ENSMUSG00000039536
	O95793
	Q9Z108
NM_001037328; NM_004602; NM_017452; NM_017453; NM_017454;
	NM_001319134; NM_001319135; NM_001322927; NM_001322928; NM_001322929; NM_001322930; NM_001322931; NM_001322932; NM_001322933
	NM_001109905; NM_001109906; NM_001291160; NM_011490
NP_001032405; NP_001306063; NP_001306064; NP_001309856; NP_001309857;
	NP_001309858; NP_001309859; NP_001309860; NP_001309861; NP_001309862; NP_004593; NP_059346; NP_059347; NP_059348
	NP_001103375; NP_001103376; NP_001278089; NP_035620
	Wikidata
View/Edit Human	View/Edit Mouse

Double-stranded RNA-binding protein Staufen homolog 1 is a protein that in humans is encoded by the STAU1 gene.^[5]^[6]^[7]

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule-binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.^[7]

STAU1 is associated with stress granules.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124214 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039536 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ DesGroseillers L, Lemieux N (Feb 1997). "Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization". Genomics. 36 (3): 527–529. doi:10.1006/geno.1996.0499. PMID 8884277.
^ Kim YK, Furic L, Desgroseillers L, Maquat LE (Jan 2005). "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay". Cell. 120 (2): 195–208. doi:10.1016/j.cell.2004.11.050. PMID 15680326. S2CID 16786108.
^ ^a ^b "Entrez Gene: STAU1 staufen, RNA binding protein, homolog 1 (Drosophila)".
^ Thomas MG, Martinez Tosar LJ, Loschi M, Pasquini JM, Correale J, Kindler S, Boccaccio GL (January 2005). "Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes". Molecular Biology of the Cell. 16 (1): 405–420. doi:10.1091/mbc.E04-06-0516. PMC 539183. PMID 15525674.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124214 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039536 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8884277-5] DesGroseillers L, Lemieux N (Feb 1997). "Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization". Genomics. 36 (3): 527–529. doi:10.1006/geno.1996.0499. PMID 8884277.

[pmid15680326-6] Kim YK, Furic L, Desgroseillers L, Maquat LE (Jan 2005). "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay". Cell. 120 (2): 195–208. doi:10.1016/j.cell.2004.11.050. PMID 15680326. S2CID 16786108.

[entrez-7] "Entrez Gene: STAU1 staufen, RNA binding protein, homolog 1 (Drosophila)".

[8] Thomas MG, Martinez Tosar LJ, Loschi M, Pasquini JM, Correale J, Kindler S, Boccaccio GL (January 2005). "Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes". Molecular Biology of the Cell. 16 (1): 405–420. doi:10.1091/mbc.E04-06-0516. PMC 539183. PMID 15525674.

STAU1 information

and 4 Related for: STAU1 information

STAU1

Stress granule

Chromosome 20

Drosophila embryogenesis