antigen processing and presentation of exogenous peptide antigen via MHC class II
establishment or maintenance of microtubule cytoskeleton polarity
chromosome segregation
cell division
regulation of chromosome segregation
microtubule-based movement
cell cycle
microtubule depolymerization
mitotic metaphase plate congression
cell population proliferation
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
sister chromatid cohesion
metaphase plate congression
attachment of mitotic spindle microtubules to kinetochore
mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
11004
73804
Ensembl
ENSG00000142945
ENSMUSG00000028678
UniProt
Q99661
Q922S8
RefSeq (mRNA)
NM_001297655 NM_001297656 NM_001297657 NM_006845
NM_001290662 NM_134471
RefSeq (protein)
NP_001284584 NP_001284585 NP_001284586 NP_006836
NP_001277591 NP_608301
Location (UCSC)
Chr 1: 44.74 – 44.77 Mb
Chr 4: 117.02 – 117.04 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.[5][6]
The protein encoded by this gene is a member of kinesin-like protein family, and contains common ATPase site structures such as the P-loop, Switch 1, and Switch 2.[7] Most proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.[6]
A ribbon and surface diagram of the KIF2C motor domain.[8] The kinesin structure is pseudo-colored to highlight the ATPase site with a bound nucleotide. The figure then presents KIF2C binding to the tubulin dimer and finally visualizes a KIF2C motor head in the context of the microtubule filament.
^ abcGRCh38: Ensembl release 89: ENSG00000142945 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028678 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kim IG, Jun DY, Sohn U, Kim YH (December 1997). "Cloning and expression of human mitotic centromere-associated kinesin gene". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1359 (3): 181–186. doi:10.1016/s0167-4889(97)00103-1. PMID 9434124.
^ ab"Entrez Gene: KIF2C kinesin family member 2C".
^Wang W, Cantos-Fernandes S, Lv Y, Kuerban H, Ahmad S, Wang C, Gigant B (July 2017). "Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin". Nature Communications. 8 (1): 70. doi:10.1038/s41467-017-00091-9. PMC 5503940. PMID 28694425.
^"RCSB PDB - 3EDL: Kinesin13-Microtubule Ring complex". RCSB Protein Data Bank. Retrieved 2024-04-21.
Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene. The protein encoded by this gene is a member of kinesin-like protein...
Global Information
