Motor protein in humans
KIF1A Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EGX, 4EJQ, 4UXO, 4UXP, 4UXR, 4UXS
Identifiers Aliases KIF1A , ATSV, C2orf20, HSN2C, MRD9, SPG30, UNC104, kinesin family member 1AExternal IDs OMIM: 601255; MGI: 108391; HomoloGene: 99729; GeneCards: KIF1A; OMA:KIF1A - orthologs Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 240,713,761 bp[1] End 240,821,036 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 92,943,186 bp[2] End 93,029,673 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in postcentral gyrus cerebellar vermis pons amygdala dorsolateral prefrontal cortex entorhinal cortex nucleus accumbens ventral tegmental area superior vestibular nucleus inferior ganglion of vagus nerve
Top expressed in superior frontal gyrus cerebellar cortex medial dorsal nucleus habenula dorsomedial hypothalamic nucleus medial geniculate nucleus pontine nuclei subiculum dorsal tegmental nucleus ventral tegmental area
More reference expression data
BioGPS
Gene ontology Molecular function
microtubule binding
microtubule motor activity
nucleotide binding
ATPase activity
cytoskeletal motor activity
ATP binding
identical protein binding
protein homodimerization activity
plus-end-directed microtubule motor activity
Cellular component
cytoplasm
microtubule
cytoskeleton
kinesin complex
axon cytoplasm
axon
cytosol
synaptic vesicle
dendrite
neuronal cell body
presynapse
postsynapse
protein-containing complex
neuron projection
Biological process
microtubule-based movement
anterograde axonal transport
interkinetic nuclear migration
protein transport along microtubule
vesicle-mediated transport
cytoskeleton-dependent intracellular transport
anterograde neuronal dense core vesicle transport
retrograde neuronal dense core vesicle transport
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001244008 NM_004321 NM_001320705 NM_001330289 NM_001330290
NM_001110315 NM_001294149 NM_001294150 NM_008440 NM_001368847
RefSeq (protein) NP_001230937 NP_001307634 NP_001317218 NP_001317219 NP_004312
Location (UCSC) Chr 2: 240.71 – 240.82 Mb Chr 1: 92.94 – 93.03 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Kinesin-like protein KIF1A , also known as axonal transporter of synaptic vesicles or microtubule-based motor KIF1A , is a protein that in humans is encoded by the KIF1A gene.[5] [6] [7]
KIF1A is a neuron-specific member of the kinesin-3 family and is a microtubule plus end-directed motor protein involved in the anterograde, long-distance transport of vesicles and organelles. Similar to other kinesin proteins, KIF1A harnesses the chemical energy released from Adenosine Triphosphate (ATP) hydrolysis to create mechanical force, allowing it to “walk” along microtubule filaments to transport cargo from the neuron cell body to its periphery. With an important role in the brain, KIF1A function is essential for physiological processes, such as neuronal survival and higher brain function.[8]
^ a b c GRCh38: Ensembl release 89: ENSG00000130294 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014602 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: kinesin family member 1A".
^ Okada Y, Yamazaki H, Sekine-Aizawa Y, Hirokawa N (June 1995). "The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors". Cell . 81 (5): 769–80. doi:10.1016/0092-8674(95)90538-3 . PMID 7539720. S2CID 16772001.
^ Keller MP, Seifried BA, Rabin BA, Chance PF (March 1999). "Mapping of the kinesin-related gene ATSV to chromosome 2q37". Hum. Genet . 104 (3): 254–6. doi:10.1007/s004390050944. PMID 10323250. S2CID 10375316.
^ Siddiqui N, Straube A (July 2017). "Intracellular Cargo Transport by Kinesin-3 Motors" (PDF) . Biochemistry. Biokhimiia . 82 (7): 803–815. doi:10.1134/S0006297917070057. PMC 7612238 . PMID 28918744. S2CID 20811770.
Last Update: 2024-05-16T14:40:40Z
protein KIF1A , also known as axonal transporter of synaptic vesicles or microtubule-based motor KIF1A , is a protein that in humans is encoded by the KIF1A gene...
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Last Update: 2024-04-04T02:45:21Z
ISSN 2666-2477. PMC 8054982. PMID 33880452. "KIF1A .ORG | KIF1A Associated Neurological Disorder". KIF1A . Retrieved 2021-04-29. Brueckner, Martina; Lifton...
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Last Update: 2024-06-02T00:07:56Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-04-25T14:29:26Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-05-06T05:02:12Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-05-21T07:41:08Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-04-03T16:02:24Z
primary lateral sclerosis (JPLS) ALS2 Keloid disorder KIF1A -Associated neurological disorder KIF1A (2q37.3) Dominant negative Kleefstra syndrome 9q34 D...
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Last Update: 2024-04-29T01:55:48Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-04-26T06:22:51Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-05-10T22:45:07Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-02-12T12:44:15Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2023-10-15T18:04:10Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-04-20T07:37:29Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-04-03T19:42:49Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2023-11-28T02:55:01Z
Tubulin kif1a head-microtubule complex structure in atp-form Identifiers Symbol Tubulin Pfam PF00091 Pfam clan CL0442 InterPro IPR003008 PROSITE PDOC00201...
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Last Update: 2023-10-04T03:48:48Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-04-19T19:25:25Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
Word Count : 3649
Last Update: 2024-04-19T20:38:51Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
Word Count : 631
Last Update: 2023-08-31T11:02:28Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-03-10T00:27:19Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-05-10T19:26:43Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
Word Count : 6192
Last Update: 2023-09-27T06:28:26Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
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Last Update: 2024-04-23T12:39:21Z
was titled "The motility mechanism of the single-headed kinesin motor, KIF1A ". Around 2005, he and his graduate students discovered the role of Kinesin-2...
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Last Update: 2024-05-23T16:24:37Z
TUBGCP5 TUBGCP6 TUBD1 TUBE1 MAPs EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4 Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9...
Word Count : 2777