Epomediol information

Epomediol
Clinical data
Other names	1,3,3-Trimethyl-2-oxabicyclo [2.2.2]octane-6,7-endo,endo-diol
ATC code	A05BA05 (WHO) ;
Identifiers
	IUPAC name (1s,4r,6R,7S)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane-6,7-diol;
CAS Number	56084-15-2 ;
PubChem CID	115056;
ChemSpider	102967;
UNII	KFU4XSK3BK;
CompTox Dashboard (EPA)	DTXSID70971470 ;
Chemical and physical data
Formula	C10H18O3
Molar mass	186.251 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC1CC2C(OC1(C)C(O)C2)(C)C;

Epomediol (trade name Clesidren) is a synthetic terpenoid with choleretic effects. It has been used in the symptomatic treatment of itching due to intrahepatic cholestasis of pregnancy.^[1]^[2]^[3]

^ Gonzalez MC, Iglesias J, Tiribelli C, et al. (September 1992). "Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy". J Hepatol. 16 (1–2): 241–2. doi:10.1016/S0168-8278(05)80122-9. PMID 1484159.
^ Reyes H (December 1992). "The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy". Gastroenterol Clin North Am. 21 (4): 905–21. PMID 1478743.
^ Reyes H, Simon FR (August 1993). "Intrahepatic cholestasis of pregnancy: an estrogen-related disease". Semin Liver Dis. 13 (3): 289–301. doi:10.1055/s-2007-1007357. PMID 8235718.

[1] Gonzalez MC, Iglesias J, Tiribelli C, et al. (September 1992). "Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy". J Hepatol. 16 (1–2): 241–2. doi:10.1016/S0168-8278(05)80122-9. PMID 1484159.

[2] Reyes H (December 1992). "The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy". Gastroenterol Clin North Am. 21 (4): 905–21. PMID 1478743.

[3] Reyes H, Simon FR (August 1993). "Intrahepatic cholestasis of pregnancy: an estrogen-related disease". Semin Liver Dis. 13 (3): 289–301. doi:10.1055/s-2007-1007357. PMID 8235718.