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An insulin analog (also called an insulin analogue) is any of several types of medical insulin that are altered forms of the hormone insulin, different from any occurring in nature, but still available to the human body for performing the same action as human insulin in terms of controlling blood glucose levels in diabetes. Through genetic engineering of the underlying DNA, the amino acid sequence of insulin can be changed to alter its ADME (absorption, distribution, metabolism, and excretion) characteristics. Officially, the U.S. Food and Drug Administration (FDA) refers to these agents as insulin receptor ligands (because, like insulin itself, they are ligands of the insulin receptor), although they are usually just referred to as insulin analogs or even (loosely but commonly) just insulin (without further specification).
These modifications have been used to create two types of insulin analogs: those that are more readily absorbed from the injection site and therefore act faster than natural insulin injected subcutaneously, intended to supply the bolus level of insulin needed at mealtime (prandial insulin); and those that are released slowly over a period of between 8 and 24 hours, intended to supply the basal level of insulin during the day and particularly at nighttime (basal insulin). The first insulin analog (insulin Lispro rDNA) was approved for human therapy in 1996 and was manufactured by Eli Lilly and Company.
An insulinanalog (also called an insulin analogue) is any of several types of medical insulin that are altered forms of the hormone insulin, different...
(prandial insulins) and long action (basal insulins). The first biosynthetic insulinanalog was developed for clinical use at mealtime (prandial insulin), Humalog...
(insulin glargine), a long-acting insulinanalog. Unlike some other longer-acting insulins, glargine must not be diluted or mixed with other insulin or...
CE, et al. (July 2021). "Molecular Engineering of Insulin Icodec, the First Acylated InsulinAnalog for Once-Weekly Administration in Humans". Journal...
mellitus by decreasing glucose levels in the blood. With the exception of insulin, most GLP-1 receptor agonists (liraglutide, exenatide, and others), and...
Insulin lispro, sold under the brand name Humalog among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. It is...
Insulin degludec (INN/USAN) is an ultralong-acting basal insulin analogue that was developed by Novo Nordisk under the brand name Tresiba. It is administered...
Insulin aspart, sold under the brand name NovoLog, among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. It is...
Neutral Protamine Hagedorn (NPH) insulin, also known as isophane insulin, is an intermediate-acting insulin given to help control blood sugar levels in...
An insulin pump is a medical device used for the administration of insulin in the treatment of diabetes mellitus, also known as continuous subcutaneous...
Regular insulin, also known as neutral insulin and soluble insulin, is a type of short-acting medical insulin. It is used to treat type 1 diabetes, type...
It works by decreasing glucose production in the liver, increasing the insulin sensitivity of body tissues, and increasing GDF15 secretion, which reduces...
to enhance growth of pancreatic beta cells, which are responsible for insulin production and release. Additionally, it inhibits the production of glucagon...
Untethered regimen, a technique combining the use of an insulin pump with a slow-acting insulinanalog "Untethered" (Law & Order: Criminal Intent), 2007 Untethered...
administration, with some effects lasting over 24 hours. Lente insulin products, along with other insulinanalogs in the same family, were discontinued by their manufacturers...
secreted by cells of the intestines, and in turn cause the secretion of insulin. Tirzepatide is a long-acting GIP-analogue that activates both the GLP-1...
being unable to produce insulin and one of the actions of dulaglutide is to stimulate functioning islet cells to produce more insulin. Dulaglutide can be...
Insulin tregopil is a fast-acting insulinanalog, unlike other forms of insulin it is delivered by mouth. It is developed by Biocon for diabetes. Joshi...
Insulin efsitora alfa (LY3209590) is a novel insulinanalog developed by Eli Lilly for the treatment of diabetes. Glycemic control and safety were found...
Insulin detemir, sold under the brand name Levemir among others, is a long-acting modified form of medical insulin used to treat both type 1 and type 2...
standard of basal insulin. Long-acting insulinanalogs such as insulin glargine (brand name Lantus, made by Sanofi-Aventis) and insulin detemir (brand name...
increasing secretion of insulin from the beta cells in the pancreas. Sulfonylureas are ineffective where there is absolute deficiency of insulin production such...
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