In vitro toxicity testing is the scientific analysis of the toxic effects of chemical substances on cultured bacteria or mammalian cells.[1]In vitro (literally 'in glass') testing methods are employed primarily to identify potentially hazardous chemicals and/or to confirm the lack of certain toxic properties in the early stages of the development of potentially useful new substances such as therapeutic drugs, agricultural chemicals and food additives.
In vitro assays for xenobiotic toxicity are recently carefully considered by key government agencies (e.g., EPA; NIEHS/NTP; FDA), to better assess human risks. There are substantial activities in using in vitro systems to advance mechanistic understanding of toxicant activities, and the use of human cells and tissue to define human-specific toxic effects.[2]
^Gavanji S, Bakhtari A, Famurewa AC, Othman EM (January 2023). "Cytotoxic Activity of Herbal Medicines as Assessed in Vitro: A Review". Chemistry & Biodiversity. 20 (2): 3–27. doi:10.1002/cbdv.202201098. PMID 36595710. S2CID 255473013.
^"Tox21". Source: U.S. Environmental Protection Agency. Retrieved 2011-10-29.
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ToxicologyinVitro is a peer-reviewed scientific journal covering invitrotoxicology. It is published semi-quarterly by Elsevier and an official journal...
testing methods in toxicology has been published by Balls. Computer modeling is an example of an alternative invitrotoxicology testing method; using...
consequence, many sophisticated techniques including Ames Assay, invitro and in vivo Toxicology Tests, and Comet Assay have been developed to assess the chemicals'...
Toxicology testing is commonly conducted during preclinical development for a substance intended for human exposure. Stages of in silico, invitro and...
irritation test as the validation standard for invitro methods. In: Goldber AM (Ed): InVitroToxicology: Approaches to Validation. New York, Mary Ann...
Ovarian culture is an in-vitro process that allows for the investigation of the development, toxicology and pathology of the ovary. This technique can...
as toxicology where animal experiments are being phased out and are increasingly being replaced by alternative tests. Results obtained from invitro experiments...
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human development, certain genetic disease, and invitrotoxicology testing. According to a 2002 article in PNAS, "Human embryonic stem cells have the potential...
Forensic toxicology is a multidisciplinary field that combines the principles of toxicology with expertise in disciplines such as analytical chemistry...
HepaRG cell line is a human hepatic invitro line used in liver biology research and for assessing liver pathology, hepatotoxicity, and drug-induced injury...
derived from toad (Bufo bufo gargarizans Canto) venom in guinea-pigs in vivo and invitro". Toxicology Mechanisms and Methods. 22 (1): 1–8. doi:10.3109/15376516...
"Effects of Currently Used Pesticides in Assays for Estrogenicity, Androgenicity, and Aromatase Activity inVitro". Toxicology and Applied Pharmacology. 179 (1):...
"Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity invitro". Toxicology and Applied Pharmacology. 179 (1):...
Engineering, and Medicine, "Laboratory tests of e-cigarette ingredients, invitrotoxicological tests, and short-term human studies suggest that e-cigarettes are...
Data. Animal products in pharmaceuticals Canadian Centre for Alternatives to Animal Methods Humane Research Trust Invitrotoxicology R E Hester R M Harrison...
acid against hydrogen peroxide in yeast cells". ToxicologyinVitro. Twelfth International Workshop on InvitroToxicology. 17 (5–6): 753–9. doi:10.1016/j...
Applied Toxicology is a monthly peer-reviewed scientific journal published since 1981 by John Wiley & Sons. It covers all aspects of toxicology and publishes...
Proliferation Assay in the Flatworm Model Macrostomum lignano to Predict the Carcinogenicity of Compounds". Applied inVitroToxicology. 1 (3): 213–219....
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