PSMB6 information

PSMB6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4R3O, 4R67, 5A0Q
Identifiers
Aliases	PSMB6, DELTA, LMPY, proteasome subunit beta 6, Y, proteasome 20S subunit beta 6
External IDs	OMIM: 600307; MGI: 104880; HomoloGene: 2092; GeneCards: PSMB6; OMA:PSMB6 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,796,144 bp[1] End 4,798,502 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 42.99 cM Start 70,416,193 bp[2] End 70,418,684 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle body of tongue left ventricle islet of Langerhans smooth muscle tissue rectum triceps brachii muscle left coronary artery prefrontal cortex right adrenal gland Top expressed in saccule otic placode medial ganglionic eminence primitive streak somite maxillary prominence facial motor nucleus yolk sac abdominal wall internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function endopeptidase activity peptidase activity threonine-type endopeptidase activity hydrolase activity cadherin binding Cellular component nucleoplasm proteasome complex extracellular exosome nucleus proteasome core complex cytoplasm cytosol proteasome core complex, beta-subunit complex Biological process regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade proteolysis Fc-epsilon receptor signaling pathway NIK/NF-kappaB signaling anaphase-promoting complex-dependent catabolic process proteolysis involved in cellular protein catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process viral process Wnt signaling pathway, planar cell polarity pathway negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5694 19175 Ensembl ENSG00000142507 ENSMUSG00000018286 UniProt P28072 Q60692 RefSeq (mRNA) NM_002798 NM_001270481 NM_008946 RefSeq (protein) NP_001257410 NP_002789 NP_032972 Location (UCSC) Chr 17: 4.8 – 4.8 Mb Chr 11: 70.42 – 70.42 Mb PubMed search [3] [4]
Wikidata
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Proteasome subunit beta type-6 also known as 20S proteasome subunit beta-1 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB6 gene.^[5][6][7]

This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-6, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Caspase-like" activity and is capable of cleaving after acidic residues of peptide.^[8] The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.