PSME1 information

PSME1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AVO
Identifiers
Aliases	PSME1, IFI5111, PA28A, PA28alpha, REGalpha, HEL-S-129m, proteasome activator subunit 1
External IDs	OMIM: 600654; MGI: 1096367; HomoloGene: 4560; GeneCards: PSME1; OMA:PSME1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,138,967 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,818,986 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; lymph node; ; spleen; ; right adrenal gland; ; duodenum; ; right adrenal cortex; ; appendix; ; left adrenal gland; ; rectum;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; duodenum; ; right ventricle; ; thymus; ; right lung lobe; ; jejunum; ; blood; ; left lung; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activator activity; protein binding;
Cellular component	proteasome complex; cytoplasm; nucleoplasm; proteasome activator complex; cytosol; extracellular exosome;
Biological process	tumor necrosis factor-mediated signaling pathway; protein polyubiquitination; T cell receptor signaling pathway; positive regulation of canonical Wnt signaling pathway; anaphase-promoting complex-dependent catabolic process; regulation of proteasomal protein catabolic process; regulation of G1/S transition of mitotic cell cycle; regulation of mRNA stability; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous antigen; regulation of cellular amino acid metabolic process; NIK/NF-kappaB signaling; Fc-epsilon receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; MAPK cascade; stimulatory C-type lectin receptor signaling pathway; positive regulation of endopeptidase activity; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5720
	19186
	ENSG00000092010; ENSG00000284916
	ENSMUSG00000022216
	Q06323
	P97371
	NM_176783; NM_001281528; NM_001281529; NM_006263
	NM_011189
	NP_001268457; NP_001268458; NP_006254; NP_788955
	NP_035319
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome activator complex subunit 1 is a protein that in humans is encoded by the PSME1 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000284916 GRCh38: Ensembl release 89: ENSG00000092010, ENSG00000284916 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022216 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Honoré B, Leffers H, Madsen P, Celis JE (Feb 1994). "Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111". Eur J Biochem. 218 (2): 421–30. doi:10.1111/j.1432-1033.1993.tb18392.x. PMID 8269930.
^ "Entrez Gene: PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)".

[refGRCh38Ensembl-1] ENSG00000284916 GRCh38: Ensembl release 89: ENSG00000092010, ENSG00000284916 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022216 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8269930-5] Honoré B, Leffers H, Madsen P, Celis JE (Feb 1994). "Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111". Eur J Biochem. 218 (2): 421–30. doi:10.1111/j.1432-1033.1993.tb18392.x. PMID 8269930.

[entrez-6] "Entrez Gene: PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)".

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