PSME2 information

PSME2
Identifiers
Aliases	PSME2, PA28B, PA28beta, REGbeta, proteasome activator subunit 2
External IDs	OMIM: 602161; MGI: 1096365; HomoloGene: 86889; GeneCards: PSME2; OMA:PSME2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,147,570 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,828,570 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; duodenum; ; appendix; ; spleen; ; right adrenal cortex; ; mucosa of transverse colon; ; lymph node; ; pituitary gland; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	jejunum; ; duodenum; ; ileum; ; colon; ; adrenal gland; ; ovary; ; uterus; ; epiblast; ; spleen; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activator activity; protein binding; identical protein binding;
Cellular component	cytoplasm; cytosol; membrane; proteasome activator complex; nucleoplasm; proteasome complex; extracellular exosome;
Biological process	positive regulation of endopeptidase activity; regulation of proteasomal protein catabolic process; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; positive regulation of canonical Wnt signaling pathway; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; Fc-epsilon receptor signaling pathway; regulation of G1/S transition of mitotic cell cycle; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; interleukin-12-mediated signaling pathway; regulation of hematopoietic stem cell differentiation; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5721
	19188
	ENSG00000100911; ENSG00000284889
	ENSMUSG00000079197
	Q9UL46
	P97372
	NM_002818
	NM_001029855; NM_011190
	NP_002809
	NP_001268401
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome activator complex subunit 2 is a protein that in humans is encoded by the PSME2 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000284889 GRCh38: Ensembl release 89: ENSG00000100911, ENSG00000284889 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079197 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, Chung CH, Shibmara N, Willy PJ, Mott JD (Jul 1995). "Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome". FEBS Lett. 366 (1): 37–42. doi:10.1016/0014-5793(95)00492-R. PMID 7789512.
^ "Entrez Gene: PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)".

[refGRCh38Ensembl-1] ENSG00000284889 GRCh38: Ensembl release 89: ENSG00000100911, ENSG00000284889 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079197 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7789512-5] Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, Chung CH, Shibmara N, Willy PJ, Mott JD (Jul 1995). "Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome". FEBS Lett. 366 (1): 37–42. doi:10.1016/0014-5793(95)00492-R. PMID 7789512.

[entrez-6] "Entrez Gene: PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)".

PSME2 information

and 4 Related for: PSME2 information

PSME2

Housekeeping gene

PSME1

Fam158a