Mechanism of class-switch recombination that allows isotype switching in activated B cells.
Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG.[1] During this process, the constant-region portion of the antibody heavy chain is changed, but the variable region of the heavy chain stays the same (the terms variable and constant refer to changes or lack thereof between antibodies that target different epitopes). Since the variable region does not change, class switching does not affect antigen specificity. Instead, the antibody retains affinity for the same antigens, but can interact with different effector molecules.
^Bauer G (2020). "The variability of the serological response to SARS-corona virus-2: Potential resolution of ambiguity through determination of avidity (functional affinity)". Journal of Medical Virology. 93 (1): 311–322. doi:10.1002/jmv.26262. PMC 7361859. PMID 32633840.
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Immunoglobulinclassswitching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that...
surface receptor CD40, which promotes B cell proliferation, immunoglobulinclassswitching, and somatic hypermutation as well as sustains T cell growth...
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type of DNA rearrangement, a process called Immunoglobulinclassswitching. IgM is the first immunoglobulin expressed in the human fetus (around 20 weeks)...
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are caused by an excess of immunoglobulin M (IgM), because this is the default immunoglobulin type prior to classswitching. Some types of hypergammaglobulinemia...
Immunoglobulin A (Ig A, also referred to as sIgA in its secretory form) is an antibody that plays a role in the immune function of mucous membranes. The...
somatic hypermutation. This somatic hypermutation allows for immunoglobulinclassswitching but also results in affinity maturation of the antibody. The...
An antibody (Ab) is the secreted form of a B cell receptor; the term immunoglobulin (Ig) can refer to either the membrane-bound form or the secreted form...
communication. A defect in this gene results in an inability to undergo immunoglobulinclassswitching and is associated with hyper IgM syndrome. Absence of CD154...
genetic recombination, called immunoglobulinclassswitching. It is a biological mechanism that changes an antibody from one class to another, for example,...
experience severe immunosuppression. This syndrome is also known as immunoglobulinclassswitch recombination (Ig-CSR) deficiencies. The most common causes are...
Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually...
human antigen-presenting cells, which consequated in defective immunoglobulinclassswitching and improper organization of the secondary lymphoid tissue....
differentiation and eventual classswitching occurrence. For example, interleukin-4 induces the rearrangements of heavy chain immunoglobulin genes. That is IL-...
Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has been found only in mammals. IgE is synthesised by plasma cells...
region of the Myc family of oncogenes. They also function in immunoglobulinclassswitching and may play a role in the genome of HIV. Guanine tetrads appear...
(March 1997). "B7-1 and B7-2 have overlapping, critical roles in immunoglobulinclassswitching and germinal center formation". Immunity. 6 (3): 303–13. doi:10...
immunoglobulin M deficiency is a poorly defined dysgammaglobulinemia characterized by decreased levels of IgM while levels of other immunoglobulins are...
Immunogenicity Immunoglobulin A ImmunoglobulinclassswitchingImmunoglobulin D Immunoglobulin E Immunoglobulin G Immunoglobulin heavy chain Immunoglobulin light...
mobilization of the immune system. Over time, immunoglobulinclassswitching will result in IgM-generating B-cells switching to more specific IgG-generating B-cells...
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