Presence of cells originating from another individual
During pregnancy, a two-way traffic of immune cells may occur through the placenta. Exchanged cells can multiply and establish long-lasting cell lines that are immunologically active even decades after giving birth.
Microchimerism is the presence of a small number of cells in an individual that have originated from another individual and are therefore genetically distinct. This phenomenon may be related to certain types of autoimmune diseases although the responsible mechanisms are unclear. The term comes from the prefix "micro" + "chimerism" based on the hybrid Chimera of Greek mythology. The concept was first discovered in the 1960s with the term gaining usage in the 1970s.[1]
^Naik, Rupali; Shrivastava, Sandhya; Suryawanshi, Hema; Gupta, Neha (2019). "Microchimerism: A new concept". Journal of Oral and Maxillofacial Pathology. 23 (2). Medknow: 311. doi:10.4103/jomfp.jomfp_85_17. ISSN 0973-029X. PMC 6714269. PMID 31516258.
mammals), the most common form is fetomaternal microchimerism (also known as fetal cell microchimerism or fetal chimerism) whereby cells from a fetus...
study suggests that possible reasons for occurrence of male chromosome microchimerism could be one of the following: miscarriages, pregnancies, vanished male...
male twin, via vascular connections between placentas: an example of microchimerism. The chimerism is mainly present in the hematopoietic stem cells. Freemartins...
medical geneticist and neonatologist noted for her research on fetal cell microchimerism and prenatal testing. Bianchi had previously been the Natalie V. Zucker...
suspected mechanisms behind the autoimmune phenomenon is the existence of microchimerism, i.e. fetal cells circulating in maternal blood, triggering an immune...
Stormie Jones at Children's Hospital of Pittsburgh in 1984; Proposing microchimerism in organ transplant tolerance. Benjamin Franklin Medal for Distinguished...
implications for identity surrounding the phenomenon of fetomaternal microchimerism and other forms of genetic chimeras. Her dissertation on the history...
(November 2006). ""(November 2006). "No evidence for maternal-fetal microchimerism in infantile hemangioma: a molecular genetic investigation". J. Invest...
peripheral blood stem cell transplantation" 2014 The Existence and Role of Microchimerism after Microtransplantion 2014 Malposition of peripherally inserted central...
doi:10.1097/00007890-199011000-00014. PMID 2238057. Nelson JL (2002). "Microchimerism: incidental byproduct of pregnancy or active participant in human health...
M., Fortunato, A., Wilson Sayres, M., & Aktipis, A. (2015). "Fetal microchimerism and maternal health: A review and evolutionary analysis of cooperation...
KM, Nelson JL (2008). "Autoimmune disease during pregnancy and the microchimerism legacy of pregnancy". Immunological Investigations. 37 (5): 631–644...
"microtransplantation" comes from its mechanism of reaching donor cell microchimerism. Chemotherapy is used by lower doses only to destroy cancer and partially...
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