Micrograph of the primitive neuroepithelium of an immature teratoma. H&E stain.
Specialty
Oncology
An immature teratoma is a teratoma that contains anaplastic immature elements, and is often synonymous with malignant teratoma.[1] A teratoma is a tumor of germ cell origin, containing tissues from more than one germ cell line,[2][3][4] It can be ovarian or testicular in its origin.[4] and are almost always benign.[5] An immature teratoma is thus a very rare tumor, representing 1% of all teratomas, 1% of all ovarian cancers, and 35.6% of malignant ovarian germ cell tumors.[6] It displays a specific age of incidence, occurring most frequently in the first two decades of life and almost never after menopause.[4] Unlike a mature cystic teratoma, an immature teratoma contains immature or embryonic structures. It can coexist with mature cystic teratomas and can constitute of a combination of both adult and embryonic tissue.[7][8] The most common symptoms noted are abdominal distension and masses.[9] Prognosis and treatment options vary and largely depend on grade, stage and karyotype of the tumor itself.
^Sun H, Ding H, Wang J, Zhang E, Fang Y, Li Z, et al. (April 2019). "The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy". BMC Cancer. 19 (1): 408. doi:10.1186/s12885-019-5598-0. PMC 6492338. PMID 31039746.
^"NCI Dictionary of Cancer Terms". National Cancer Institute. 2011-02-02. Retrieved 2018-04-20.
^Damjanov I (2009). Pathology secrets (3rd ed.). Philadelphia, PA: Mosby/Elsevier. ISBN 9780323055949. OCLC 460883266.
^ abcUlbright TM (January 2004). "Gonadal teratomas: a review and speculation". Advances in Anatomic Pathology. 11 (1): 10–23. doi:10.1097/00125480-200401000-00002. PMID 14676637.
^Schmidt D, Kommoss F (May 2007). "[Teratoma of the ovary. Clinical and pathological differences between mature and immature teratomas]". Der Pathologe (in German). 28 (3): 203–8. doi:10.1007/s00292-007-0909-7. PMID 17396268.
^Alwazzan AB, Popowich S, Dean E, Robinson C, Lotocki R, Altman AD (November 2015). "Pure Immature Teratoma of the Ovary in Adults: Thirty-Year Experience of a Single Tertiary Care Center". International Journal of Gynecological Cancer. 25 (9): 1616–22. doi:10.1097/IGC.0000000000000541. PMC 4623850. PMID 26332392.
^Coran AG, Adzick NS (2012). Pediatric surgery (7th ed.). Philadelphia, PA: Elsevier Mosby. pp. 539–548. ISBN 9780323072557. OCLC 778785699.
^Di Saia PJ, Creasman WT (2012). Clinical gynecologic oncology (8th ed.). Philadelphia, PA: Elsevier/Saunders. pp. 329–356. ISBN 9780323074193. OCLC 785577276.
^Ki EY, Byun SW, Choi YJ, Lee KH, Park JS, Lee SJ, Hur SY (2013-06-21). "Clinicopathologic review of ovarian masses in Korean premenarchal girls". International Journal of Medical Sciences. 10 (8): 1061–7. doi:10.7150/ijms.6216. PMC 3691806. PMID 23801894.
An immatureteratoma is a teratoma that contains anaplastic immature elements, and is often synonymous with malignant teratoma. A teratoma is a tumor...
mature and immature. Mature teratomas include dermoid cysts and are generally benign. Immatureteratomas may be cancerous. Most ovarian teratomas are mature...
Sacrococcygeal teratomas are benign 75% of the time, malignant 12% of the time, and the remainder are considered "immatureteratomas" that share benign...
immature teratomas, but carcinoembryonic antigen (CEA), CA-125, CA19-9, or AFP can sometimes indicate an immatureteratoma. Stage I teratomas make up the...
observed. Teratoma are most common germ cell tumor of ovary. Teratomas can be divided into two types: mature teratoma (benign) and immatureteratoma (malignant)...
a common form is teratoma with endodermal sinus tumor. Teratocarcinoma refers to a germ cell tumor that is a mixture of teratoma with embryonal carcinoma...
include thymoma, lymphoma, pheochromocytoma, germ cell tumors including teratoma, thyroid tissue, and parathyroid lesions. Masses in this area are more...
Growing teratoma syndrome is a rare complication of teratoma that can occur when an immature ovarian germ cell teratoma is treated by chemotherapy. "Ovarian...
cystic teratomas (0.17 to 2% risk of ovarian cancer): Mandal, Shramana; Badhe, Bhawana A. (2012). "Malignant Transformation in a Mature Teratoma with Metastatic...
Epignathus is a rare teratoma of the oropharynx. Epignathus is a form of oropharyngeal teratoma that arises from the palate and, in most cases, results...
Teratoma, NOS Solid teratoma M9080/3 Teratoma, malignant, NOS Embryonal teratoma Teratoblastoma, malignant Immatureteratoma, malignant or NOS M9081/3 Teratocarcinoma...
alpha-fetoprotein with yolk sac tumors, as well as embryonic cell carcinomas and immatureteratomas and beta-HCG, which occur in choriocarcinomas. In one to 15% of germinomas...
muscle fibres and clusters of glomeruloid structures and immature tubules. Sacrococcygeal teratoma with nephroblastoma was reported by Ward and Dehner and...
of a teratoma, a tumour that characteristically has tissue from all three germ layers. The image shows tissue derived from the mesoderm (immature cartilage...
congential/neonatal tumors are uncommon (choroid plexus papillomas, craniopharyngiomas, teratomas); even when they present, they are different from the inflammatory ring...
types, teratomas, and malignant GCTs. Lists of these two categories and its subtypes are shown below. Teratomas Mature teratomasImmatureteratomas Malignant...
"EFA6A-like antibodies in paraneoplastic encephalitis associated with immature ovarian teratoma: a case report". J Neurooncol. 81 (1): 71–74. doi:10.1007/s11060-006-9200-7...
At ultrasound, teratomas generally form well-circumscribed complex masses. Echogenic foci representing calcification, cartilage, immature bone and fibrosis...
pluripotent, as they can form embryoid body-like structures (EBs) in vitro and teratoma-like structures that contained tissues derived from all three embryonic...
pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be excluded before treatment is started. Treatment includes complete surgical...
PMID 19291117. Sunita Singh; Jiledar Rawat; Intezar Ahmed (2011). "Immature extragastric teratoma of infancy: a rare tumour with review of the literature". Case...
proliferate abnormally and injure various tissues. Megakaryoblasts are the most immature precursor cells in a platelet-forming lineage; they mature to promegakaryocytes...
differentiation are self-renewable over generations. Muse cells do not undergo teratoma formation when transplanted into a host environment in vivo, eradicating...
or adult fibroblasts to pluripotent stem cells (capable of producing teratomas in vivo and contributing to chimeric mice). These pluripotent cells are...
injected into mice, the immune system of the synergeic mouse rejected the teratomas forming. Part of this may be because the immune system recognized epigenetic...
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