Hereditary nonpolyposis colorectal cancer information
Autosomal dominant genetic condition associated with a high risk of cancer in the colon
Medical condition
Hereditary nonpolyposis colorectal cancer
Micrograph showing tumor-infiltrating lymphocytes (in a colorectal cancer), a finding associated with MSI-H tumours, as may be seen in Lynch syndrome. H&E stain.
Specialty
Oncology
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.
HNPCC includes (and was once synonymous with)[1]Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin.[2] The increased risk for these cancers is due to inherited genetic mutations that impair DNA mismatch repair. It is a type of cancer syndrome.
Other HNPCC conditions include Lynch-like syndrome, polymerase proofreading-associated polyposis and familial colorectal cancer type X.[1]
^ abCarethers, John M; Stoffel, Elena M (2015-08-21). "Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer". World Journal of Gastroenterology. 21 (31): 9253–9261. doi:10.3748/wjg.v21.i31.9253. ISSN 1007-9327. PMC 4541378. PMID 26309352.
^Kastrinos F, Mukherjee B, Tayob N, Wang F, Sparr J, Raymond VM, et al. (October 2009). "Risk of pancreatic cancer in families with Lynch syndrome". JAMA. 302 (16): 1790–5. doi:10.1001/jama.2009.1529. PMC 4091624. PMID 19861671.
and 29 Related for: Hereditary nonpolyposis colorectal cancer information
Hereditarynonpolyposiscolorectalcancer (HNPCC) is a hereditary predisposition to colon cancer. HNPCC includes (and was once synonymous with) Lynch syndrome...
associated with higher rates of colorectalcancer. The most common of these is hereditarynonpolyposiscolorectalcancer (HNPCC, or Lynch syndrome) which...
authorities also refer to hereditary genetic conditions which predispose to developing cancer, such as hereditarynonpolyposiscolorectalcancer, as a precancerous...
invasive adenocarcinomas. The most frequent mutations in Hereditarynonpolyposiscolorectalcancer (HNPCC) are mutations in the MSH2 and MLH1 genes. These...
on chromosome 3. The gene is commonly associated with hereditarynonpolyposiscolorectalcancer. Orthologs of human MLH1 have also been studied in other...
with microsatellite instability and some cancers, especially with hereditarynonpolyposiscolorectalcancer (HNPCC). At least 114 disease-causing mutations...
and hMSH2 with hMSH6: examination of mutations found in hereditarynonpolyposiscolorectalcancer". Mol Cell Biol. 18 (11): 6616–23. doi:10.1128/mcb.18...
person gets such a cancer, it is often associated with hereditary syndromes like Peutz-Jegher's, hereditarynonpolyposiscolorectalcancer, or familial adenomatous...
oily skin types, with some rheumatic disorders, and in hereditarynonpolyposiscolorectalcancer. In the latter, the most common site for Fordyce spots...
BRCA2 with a more than 75% risk of breast cancer and ovarian cancer, and hereditarynonpolyposiscolorectalcancer (HNPCC or Lynch syndrome), which is present...
which are likely to have Lynch syndrome, also known as hereditarynonpolyposiscolorectalcancer (HNPCC). The Amsterdam criteria arose as a result of a...
type 1, neurofibromatosis type 2, Marfan syndrome, hereditarynonpolyposiscolorectalcancer, hereditary multiple exostoses (a highly penetrant autosomal...
suspected hereditary predisposition. The main hereditary predispositions are mainly neurofibromatosis type I, Li-Fraumeni syndrome, hereditarynonpolyposis colorectal...
ureteral cancer. HNPCC (hereditarynonpolyposiscolorectalcancer), also known as lynch syndrome, leads to an increased risk of developing ureteral cancer, as...
observed in the condition known as Lynch syndrome or hereditarynonpolyposiscolorectalcancer, while biallelic mutations are observed in CMMR-D. People...
(December 1996). "Prophylactic colectomy in patients with hereditarynonpolyposiscolorectalcancer". Annals of Medicine. 28 (6): 479–482. doi:10.3109/07853899608999111...
(formerly HereditaryNonpolyposisColorectalCancer, HNPCC), characterized by a greatly increased risk of colorectal and endometrial cancer, plus a moderately...
Guidelines for hereditarynonpolyposiscolorectalcancer (Lynch syndrome) and microsatellite instability". Journal of the National Cancer Institute. 96...
known as hereditarynonpolyposiscolorectalcancer (also known as Lynch syndrome), which confers a higher risk for developing a number of cancers, including...
repair to be less effective than normal. In particular, Hereditarynonpolyposiscolorectalcancer (HNPCC) is strongly associated with specific mutations...
has been found in two individuals with a phenotype of hereditarynonpolyposiscolorectalcancer, and without any frank MLH1 mutation which otherwise causes...
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