Hepatocellular carcinoma in an individual who was hepatitis C positive. Autopsy specimen.
Specialty
Oncology
Hepatocellular carcinoma (HCC[1]) is the most common type of primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis.[2] HCC is the third leading cause of cancer-related deaths worldwide.[3]
The development of HCC is attributed to fibrosis and cirrhosis, which occur in the setting of chronic liver injury and inflammation. The latter being closely linked to chronic viral hepatitis infection (hepatitis B or C) or exposure to toxins such as alcohol, aflatoxin, or pyrrolizidine alkaloids.[4] Certain diseases, such as hemochromatosis and alpha 1-antitrypsin deficiency, markedly increase the risk of developing HCC. Metabolic syndrome and NASH are also increasingly recognized as risk factors for HCC.[5]: 870–873
As with any cancer, the treatment and prognosis of HCC vary depending on the specifics of tumor histology, size, how far the cancer has spread, and overall health.
The vast majority of HCC cases and the lowest survival rates after treatment occur in Asia and sub-Saharan Africa, in countries where hepatitis B infection is endemic and many are infected from birth. The incidence of HCC in the United States and other developing countries is increasing due to an increase in hepatitis C virus infections. It is more than three times as common in males as in females, for unknown reasons.[5]: 870–873
^Cite error: The named reference shetty was invoked but never defined (see the help page).
^"Global Cancer Observatory". gco.iarc.fr. Retrieved 2021-06-24.
^Tan DJ, Wong C, Ng CH, Poh CW, Jain SR, Huang DQ, Muthiah MD (January 2021). "A Meta-Analysis on the Rate of Hepatocellular Carcinoma Recurrence after Liver Transplant and Associations to Etiology, Alpha-Fetoprotein, Income and Ethnicity". Journal of Clinical Medicine. 10 (2): 238. doi:10.3390/jcm10020238. PMC 7828059. PMID 33440759.
^ abKumar V, Fausto N, Abbas A, eds. (2015). Robbins & Cotran Pathologic Basis of Disease (9th ed.). Saunders. ISBN 978-1-4557-2613-4.
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