Hemagglutinin esterase (HEs) is a glycoprotein that certain enveloped viruses possess and use as an invading mechanism. HEs helps in the attachment and destruction of certain sialic acid receptors that are found on the host cell surface.[1] Viruses that possess HEs include influenza C virus, toroviruses, and coronaviruses of the subgenus Embecovirus (which does not include SARS-like coronaviruses). HEs is a dimer transmembrane protein consisting of two monomers, each monomer is made of three domains. The three domains are: membrane fusion, esterase, and receptor binding domains.
The different HEs enzyme activities include: receptor binding activity, receptor hydrolysis (esterase) activity, and membrane fusion activity. The receptor binding activity involve the attachment of HEs to N-acetyl-9-O-acetylneuraminic acid (9-O-Ac- Neu5Ac) of glycolipids and glycoproteins and in turn serve as viral receptor.[2] Receptor hydrolysis (esterase) activity allows virus particles to escape the infected cell by removing an acetyl group from the C9 position of terminal 9-O-Ac-Neu5Ac residues.[2] Membrane fusion activity helps in incorporation viral genome into the host cell cytoplasm by enhancing the attachment between the viral envelope and host cell membrane.
In certain influenza viruses, the cell surface consists of both hemagglutinin (HA) and neuraminidase (NA) proteins that encompass enzymatic activities, whereas hemagglutinin-esterase fusion (HEF) proteins have been found to be the primary single spike protein that combines all of the enzymatic activities listed above. HEF proteins have been tested to be high-temperature and low-pH resistant and are the primary source of virulence in viruses.[3] Influenza C have been shown to have unique HEF structure proteins that enhance its ability to infect the host cell compared to influenza A and B.
The folding of different domains in the hemagglutinin-esterase protein is important for intracellular transport of proteins from the endoplasmic reticulum to the Golgi apparatus. The presence of oligosaccharide chains in the E, F, and R domains of the HE enzyme also influence intracellular transport. Acylation of the hemagglutinin-esterase has shown to play an essential role in virus particle assembly replication. The exact process of enzyme catalytic cleavage has not yet been detailed out. However, proteolytic cleavage must occur before hemagglutinin-esterase membrane fusion activity. HEF proteins have a unique spikes hexagonal arrangement. This feature is unique to influenza C virus particles. The arrangement is a covering outside of the particle.
^Zeng Q, Langereis MA, van Vliet AL, Huizinga EG, de Groot RJ (July 2008). "Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution". Proceedings of the National Academy of Sciences of the United States of America. 105 (26): 9065–9. Bibcode:2008PNAS..105.9065Z. doi:10.1073/pnas.0800502105. PMC 2449365. PMID 18550812.
^ abWang M, Ludwig K, Böttcher C, Veit M (May 2016). "The role of stearate attachment to the hemagglutinin-esterase-fusion glycoprotein HEF of influenza C virus". Cellular Microbiology. 18 (5): 692–704. doi:10.1111/cmi.12541. PMID 26518983.
^Yu J, Hika B, Liu R, Sheng Z, Hause BM, Li F, Wang D (July 2017). "The Hemagglutinin-Esterase Fusion Glycoprotein Is a Primary Determinant of the Exceptional Thermal and Acid Stability of Influenza D Virus". mSphere. 2 (4). doi:10.1128/mSphere.00254-17. PMC 5549178. PMID 28808690.
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