Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000068024 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026313 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. Bibcode:1999PNAS...96.4868G. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
^Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999). "A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p". The Journal of Biological Chemistry. 274 (17): 11713–20. doi:10.1074/jbc.274.17.11713. PMID 10206986.
Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. Histones play a critical role in transcriptional...
deacetylase 4 (HDAC4) gene, have been linked to anorexia. While the ESRRA mutation decreases its transcriptional activity, the HDAC4 mutation increases...
nucleus and the cytoplasm, and is also membrane-associated. Class II HDACs (HDAC4, 5, 6, 7 9, and 10) are able to shuttle in and out of the nucleus, depending...
(HDAC4), which allows HDAC4 to be imported from the cytosol, where the oxidized form resides, into the nucleus. Once in the nucleus, reduced HDAC4 downregulates...
is thought to contribute to contractility. The Class IIA HDACs includes HDAC4, HDAC5, HDAC7 and HDAC9. HDACs 4 and 5 have been found to most closely resemble...
-2, -3 and -8 are related to yeast RPD3 gene; Class IIA, which includes HDAC4, -5, -7 and -9; Class IIB -6, and -10 are related to yeast Hda1 gene; Class...
NR, Vezmar M, Pelletier N, Crosato M, Heng HH, et al. (November 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional...
vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5". Sci Adv. 3 (11): e1701682. Bibcode:2017SciA....3E1682G. doi:10...
therapy. BTG2 has been shown to interact with PRMT1, HOXB9, CNOT8 and HDAC1 HDAC4 and HDAC9. It has also been studied with Pax6 and Tbr2 when observing the...
effect on the myogenesis process. circLMO7 is involved in overexpression of HDAC4 and downregulates MEF2A expression by upregulating miR-378a-3p leading to...
and proteolytic cleavage. MEF2C has been shown to interact with: EP300, HDAC4, HDAC7, HDAC9, MAPK7, SOX18 SP1, and TEAD1. SETD1A This gene is involved...