negative regulation of transcription by RNA polymerase II
cellular response to fluid shear stress
transcription, DNA-templated
spindle assembly
protein deacetylation
negative regulation of JNK cascade
circadian rhythm
negative regulation of myotube differentiation
negative regulation of transcription, DNA-templated
histone deacetylation
positive regulation of TOR signaling
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
regulation of lipid metabolic process
chromatin organization
positive regulation of protein import into nucleus
histone H4 deacetylation
positive regulation of cold-induced thermogenesis
positive regulation of protein ubiquitination
circadian regulation of gene expression
regulation of circadian rhythm
rhythmic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8841
15183
Ensembl
ENSG00000171720
ENSMUSG00000024454
UniProt
O15379
O88895
RefSeq (mRNA)
NM_003883
NM_010411
RefSeq (protein)
NP_003874 NP_001341968 NP_001341969 NP_001341970
NP_034541
Location (UCSC)
Chr 5: 141.62 – 141.64 Mb
Chr 18: 38.07 – 38.09 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.[5][6][7][8]
^ abcGRCh38: Ensembl release 89: ENSG00000171720 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024454 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Emiliani S, Fischle W, Van Lint C, Al-Abed Y, Verdin E (April 1998). "Characterization of a human RPD3 ortholog, HDAC3". Proc Natl Acad Sci U S A. 95 (6): 2795–800. Bibcode:1998PNAS...95.2795E. doi:10.1073/pnas.95.6.2795. PMC 19648. PMID 9501169.
^Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR (March 1998). "Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells". Biochem Biophys Res Commun. 242 (3): 648–52. doi:10.1006/bbrc.1997.8033. PMID 9464271.
^Montgomery, Rusty L.; Potthoff, Matthew J.; Haberland, Michael; Qi, Xiaoxia; Matsuzaki, Satoshi; Humphries, Kenneth M.; Richardson, James A.; Bassel-Duby, Rhonda; Olson, Eric N. (2008-11-03). "Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice". Journal of Clinical Investigation. 118 (11): 3588–3597. doi:10.1172/jci35847. ISSN 0021-9738. PMC 2556240. PMID 18830415.
^Bhaskara, Srividya; Chyla, Brenda J.; Amann, Joseph M.; Knutson, Sarah K.; Cortez, David; Sun, Zu-Wen; Hiebert, Scott W. (2008). "Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control". Molecular Cell. 30 (1): 61–72. doi:10.1016/j.molcel.2008.02.030. PMC 2373760. PMID 18406327.
Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice. Histones are highly alkaline proteins that package and order DNA...
as regulatory cross-talk between factors. HDAC3 has been found to be most closely related to HDAC8. HDAC3 contains a non-conserved region in the C-terminal...
class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene in chromatin...
chromosome TBL1Y gene. TBL1X has been shown to interact with: GPS2, and HDAC3, NCOA1, and NCOA2. GRCh38: Ensembl release 89: ENSG00000101849 – Ensembl...
drugs that inhibit four specific histone-modifying enzymes: HDAC1, HDAC2, HDAC3, and HDAC8. Most of the animal research with HDAC inhibitors has been conducted...
major target of SAHA HDAC3 is also a negative regulator of long term potentiation formation. McQuown et al. have shown that: KOs of HDAC3 in dorsal hippocampus...
subunit is controlled by acetylation via PCAF and by deacetylation via HDAC3 and HDAC6. These are just some examples of constantly emerging non-histone...
gondii. Farhat and colleagues showed that chromatin modifiers MORC and HDAC3 play critical roles in silencing sexual development-specific genes. In MORC-depleted...
agonist of HCA2. It is also an HDAC inhibitor (specifically, HDAC1, HDAC2, HDAC3, and HDAC8), a drug that inhibits the function of histone deacetylase enzymes...
concentrations (IC50) of 62 nM, 570 nM and 550 nM, against HDAC1, HDAC2 and HDAC3, respectively. It shows no activity against HDAC class II. The ortho-aminoanilide...
citric acid cycle. The GCS regulates glycine concentrations. HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are targets of the reduced form (open dithiol)...
alveolar rhabdomyosarcoma (aRMS) by specifically blocking the activity of HDAC3, thereby preventing epigenetic suppression of a microRNA that inhibits PAX3:FOXO1...
its longevity promoting benefits. Under basal environmental temperatures, HDAC3 primes expression of UCP1 and the brown fat thermogenic program to ensure...
known as HBI-8000. It is a benzamide HDI and inhibits Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10. Tucidinostat is approved by the Chinese FDA...
transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with...
repressors proteins. pRb interacts with the histone deacetylases HDAC1 and HDAC3. pRb binds to HDAC1 in its pocket domain in a region that is independent...
Global Information
