negative regulation of transcription by RNA polymerase II
transcription, DNA-templated
protein deacetylation
oligodendrocyte development
negative regulation of transcription, DNA-templated
histone deacetylation
chromatin organization
macroautophagy
positive regulation of mismatch repair
peptidyl-lysine deacetylation
homologous recombination
polyamine deacetylation
spermidine deacetylation
DNA repair
DNA recombination
autophagy
cellular response to DNA damage stimulus
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
83933
170787
Ensembl
ENSG00000100429
ENSMUSG00000062906
UniProt
Q969S8 Q08AP5
Q6P3E7
RefSeq (mRNA)
NM_032019 NM_001159286
NM_199198
RefSeq (protein)
NP_001152758 NP_114408
NP_954668
Location (UCSC)
Chr 22: 50.25 – 50.25 Mb
Chr 15: 89.01 – 89.01 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.[5][6][7]
Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM][7]
^ abcGRCh38: Ensembl release 89: ENSG00000100429 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000062906 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kao HY, Lee CH, Komarov A, Han CC, Evans RM (Jan 2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". J Biol Chem. 277 (1): 187–93. doi:10.1074/jbc.M108931200. PMID 11677242.
^Guardiola AR, Yao TP (Jan 2002). "Molecular cloning and characterization of a novel histone deacetylase HDAC10". J Biol Chem. 277 (5): 3350–6. doi:10.1074/jbc.M109861200. PMID 11726666.
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. Acetylation of histone core particles modulates chromatin structure and...
domains have also been found on HDAC10 which shows it may have roles in the regulation of the cell cycle. Two variants of HDAC10 have been found, both having...
benzamide HDI and inhibits Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10. Tucidinostat is approved by the Chinese FDA for relapsed or refractory...
regulates glycine concentrations. HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are targets of the reduced form (open dithiol) of (R)-lipoic acid. Most...
identified as a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac can cause severe contact dermatitis which is often hard to distinguish...
Evans RM (January 2002). "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". The Journal of Biological Chemistry. 277...
"Isolation and characterization of a novel class II histone deacetylase, HDAC10". The Journal of Biological Chemistry. 277 (8): 6656–66. doi:10.1074/jbc...