H3K27 is the 27th amino acid in Histone H3, which as a lysine is written "K" in single-letter amino acid notation. It is subject to posttranslational modification with epigenetic effects:
H3K27ac, an acetylation
H3K27me3, a tri methylation
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H3K27 is the 27th amino acid in Histone H3, which as a lysine is written "K" in single-letter amino acid notation. It is subject to posttranslational...
H3K27M: Referred to as diffuse midline glioma, H3K27 mutant. EZHIP overexpressing: Referred to as wildtype H3K27 EZHIP-DMG. EGFR-mutant: Referred to as diffuse...
correlated with silencing of the genomic region. Methylation of lysines H3K9 and H3K27 is correlated with transcriptional repression. Particularly, H3K9me3 is...
S-adenosyl-L-methionine (SAM). EZH2 is capable of mono-, di-, and tri-methylation of H3K27 and has been associated with a variety of biological functions, including...
genes, while down-regulated genes had epigenetic acetylations removed from H3K27 in nucleosomes located at the enhancers that control those genes (see Figure...
Down-regulated genes were associated with the removal of epigenetic acetylations at H3K27 in nucleosomes located at their enhancers (see Figure "A nucleosome with...
correlated with silencing of the genomic region. Methylation of lysines H3K9 and H3K27 is correlated with transcriptional repression. Particularly, H3K9me3 is...
in the H3K27 residue, PcGs were able to be recruited and revert to their original phenotypes indicating a transcriptional change in the H3K27 residue...
(Rubinstein–Taybi syndrome, X-linked intellectual disability). Misregulation of H3K4, H3K27, and H4K20 are associated with cancers. This modification alters the properties...
Epigenetics Yoo KH, Hennighausen L (November 2012). "EZH2 methyltransferase and H3K27 methylation in breast cancer". International Journal of Biological Sciences...
body. When examining the effects of repression of transcription further, H3K27, an amino acid component of a histone, becomes methylated through the interaction...
particularly repair of double-strand breaks by homologous recombinational repair. H3K27 can undergo a variety of other modifications. It can exist in mono- as well...
of EZH2 specifically prevents the methylation of histone H3 lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated...
Polycomb Repressive Complex 2, PRC2, (responsible for the trimethylation of H3K27). It plays an important role in the transcriptional silencing of the KCNQ1...
well characterised histone modification sites including H3K4, H3K9 and H3K27. Unusually for a histone, CENPA nucleosomes are not loaded together with...
from homeobox C (HOXC) locus but it recruits PRC2 to HOXD which deposits H3K27 and silences HOXD. HOTAIR is highly expressed in primary breast tumors....
association of transcription factors or polymerase on open DNA. For example, H3K27 trimethylation by the polycomb complex PRC2 causes chromosomal compaction...
Vps75 or Asf1. When in complex with the former, Rtt109 acetylates H3K9 and H3K27, but, when in complex with the latter, it preferentially acetylates H3K56...
H3K4 mono-/di-methyltransferase MLL4 and then are activated by histone H3K27 acetyltransferase p300. H3K4me1 fine-tunes the enhancer activity and function...
and H3K27 have less methylation when depressive behavior is seen. The hippocampus also experiences a number of histone methylation changes: H3K27-trimethylation...
humans is encoded by the EZH1 gene. In mice, EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound...
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