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Glucomannan
Names
IUPAC name
β(1→4)-d-gluco-d-mannoglycan
Identifiers
CAS Number
11078-31-2N
ChEBI
CHEBI:17020
KEGG
C01810
PubChem CID
24892726
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Glucomannan is a water-soluble polysaccharide that is considered a dietary fiber. It is a hemicellulose component in the cell walls of some plant species. Glucomannan is a food additive used as an emulsifier and thickener. It is a major source of mannan oligosaccharide (MOS) found in nature, the other being galactomannan, which is insoluble.[1]
Products containing glucomannan, under a variety of brand names, are marketed as dietary supplements with claims they can relieve constipation and help lower cholesterol levels.[2][3] Since 2010 they are legally marketed in Europe as helping with weight loss for people who are overweight and eating a diet with restricted calories,[3] but as of 2020[update] there was no good evidence that glucomannan helped weight loss.[4][5] Glucomannan lowers LDL cholesterol by 10 percent.[6]
Supplements containing glucomannans pose a risk for choking and bowel obstruction if they are not taken with sufficient water.[7] Other adverse effects include diarrhea, belching, and bloating; in one study people taking glucomannans had higher triglyceride levels.[8]
Glucomannans are also used to supplement animal feed for farmed animals, to cause the animals gain weight more quickly.
^Nopvichai, C; Charoenwongpaiboon, T; Luengluepunya, N; Ito, K; Muanprasat, C; Pichyangkura, R (2019). "Production and purification of mannan oligosaccharide with epithelial tight junction enhancing activity". PeerJ. 7: e7206. doi:10.7717/peerj.7206. PMC 6611449. PMID 31304065. MOS is often prepared by hydrolysis reaction of a mannose-contained glucan polymer, mainly glucomannan and galactomannan.
^"Monograph: Glucomannan - Capsule". Health Canada. May 11, 2010.
^ ab"Scientific Opinion on the substantiation of health claims related to konjac mannan (glucomannan) and reduction of body weight (ID 854, 1556, 3725), reduction of post-prandial glycaemic responses (ID 1559), maintenance of normal blood glucose concentration". EFSA Journal. 8 (10): 1798. October 2010. doi:10.2903/j.efsa.2010.1798.
^Cite error: The named reference wharton was invoked but never defined (see the help page).
^Ríos-Hoyo A, Gutiérrez-Salmeán G (June 2016). "New Dietary Supplements for Obesity: What We Currently Know". Curr Obes Rep (Review). 5 (2): 262–70. doi:10.1007/s13679-016-0214-y. PMID 27053066. S2CID 12071766. The more recent meta-analysis by Onakpoya et al. [58] revealed a non-statistically significant difference of −0.22 kg in weight loss between the glucomannan and placebo groups, contradicting the earlier meta-analysis. These conflicting results might be explained by the different inclusion criteria that the studies used to select the clinical trials analyzed. Although Sood et al. [59] found a statistically significant reduction in weight among study participants using glucomannan, this weight loss is not necessarily clinically significant; thus, the results should be interpreted carefully.
^Ho, Hoang Vi Thanh; Jovanovski, Elena; Zurbau, Andreea; Blanco Mejia, Sonia; Sievenpiper, John L.; Au-Yeung, Fei; Jenkins, Alexandra L.; Duvnjak, Lea; Leiter, Lawrence; Vuksan, Vladimir (May 2017). "A systematic review and meta-analysis of randomized controlled trials of the effect of konjac glucomannan, a viscous soluble fiber, on LDL cholesterol and the new lipid targets non-HDL cholesterol and apolipoprotein B". The American Journal of Clinical Nutrition. 105 (5): 1239–1247. doi:10.3945/ajcn.116.142158. ISSN 1938-3207.
^"Health Canada Advises Canadians that Natural Health Products containing Glucomannan May Cause Serious Choking if Used with Insufficient Fluid". Health Canada. January 29, 2010. Archived from the original on 4 February 2010.
^Cite error: The named reference Ernst2014 was invoked but never defined (see the help page).
Glucomannan is a water-soluble polysaccharide that is considered a dietary fiber. It is a hemicellulose component in the cell walls of some plant species...
linked backbone and α(1-2) and α(1-3) linked glucose branches, hence "glucomannan". It is water soluble. It is serologically similar to structures found...
and noodles. The dried corm of the konjac plant contains around 40% glucomannan gum. This polysaccharide makes konjac jelly a viscous substance that...
obesity under the brand name "Evekeo". Methylphenidate Cocaine Caffeine Glucomannan Leptin Lisdexamphetamine - US FDA approved for the treatment of binge-eating...
Shirataki noodles are made from 97% water and 3% konjac, which contains glucomannan, a water-soluble dietary fiber. They are very low in digestible carbohydrates...
militaris). These tubers contain a nutritious, starchy polysaccharide called glucomannan. Salep flour is consumed in beverages and desserts, especially in the...
fully fermented within the intestinal tract (guar gum, beta-glucan, glucomannan and pectins), but some viscous fibers are minimally or not fermented...
konnyaku (コンニャク), a Japanese thickening agent and edible jelly containing glucomannan.[citation needed] Some species are called voodoo-lily, as are some species...
known. Important examples include xylan, glucuronoxylan, arabinoxylan, glucomannan, and xyloglucan. Hemicelluloses are polysaccharides often associated...
and increased ratings of satiety. Other soluble fiber forms such as glucomannan have also been studied in relationship to blood sugar and fat digestion...
chronic constipation: effect of glucomannan". The American Journal of Gastroenterology. 84 (8): 888–91. PMID 2547312. "Glucomannan". Drugs.com. 23 May 2022....
Dipterocarpaceae trees obtained from non-marine botanical resources Uncharged Glucomannan E425 from the konjac plant obtained from non-marine botanical resources...
Chasanah, Uswatun (25 September 2020). "Modified arrowroot starch and glucomannan for preserving physicochemical properties of sweet bread". Ciência e...
orchids. It contains a nutritious starch-like polysaccharide called glucomannan. In some magical traditions, its root is called Adam and Eve Root. It...
collagen) Commercial jellies used in East Asian cuisines include the glucomannan polysaccharide gum used to make "lychee cups" from the konjac plants...
Buckinghamshire. Orchis militaris contains the nutritious polysaccharide glucomannan, and is one of the original species of orchid whose ground-up roots are...
with or without hypercholesterolemia". Another soluble fiber, konjac glucomannan, reduces LDL by 10 percent. There are two sources of cholesterol in the...
Phytophaga degrade 3 main substances: amorphous cellulose, xyloglucan and glucomannan. It was also composed of fungal sequences, acquired by gene transfer...
Fibers in a preload stimulate a feeling of fullness in the stomach. The glucomannan fiber preload is approved for weight control by European Food Safety...
decomposition, producing enzymes primarily dedicated to degradation of xylan, glucomannan, and callose (common components of hemicellulose) rather than cellulose...
Chasanah, Uswatun (25 September 2020). "Modified arrowroot starch and glucomannan for preserving physicochemical properties of sweet bread". Ciência e...
growth on arabinan (a pectin), arabinoxylan (wheat), xylan, xyloglucan, glucomannan, galactomannan, B-glucan, lichenin, and laminarin. They do grow on host-derived...
induced by T-2 toxin in chickens. Similarly, cosupplementation of modified glucomannans and selenium in the diets of chickens also consuming T-2 toxin, reduced...
Bioavailability of FB1 can be reduced by treating fumonisin-contaminated corn with glucomannans extracted from the cell wall of the yeast Saccharomyces cerevisiae. These...
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