Genetic interaction networks represent the functional interactions between pairs of genes in an organism and are useful for understanding the relation between genotype and phenotype. The majority of genes do not code for particular phenotypes. Instead, phenotypes often result from the interaction between several genes. In humans, "Each individual carries ~4 million genetic variants and polymorphisms, the overwhelming majority of which cannot be pinpointed as the single cause for a given phenotype. Instead, the effects of genetic variants may combine with one another both additively and synergistically, and each variant's contribution to a quantitative trait or disease risk could depend on the genotypes of dozens of other variants. Interactions between genetic variants, along with the environmental conditions, are likely to play a major role in determining the phenotype that arises from a given genotype.[1]" Genetic interaction networks help to understand genetic interactions by identifying such interactions between pairs of genes.[1]
Because genetic interactions provide insight into how genotype connects to phenotype in an organism, improved knowledge of genetic interactions in humans could provide crucial insight into complex diseases. Unfortunately, due to the impossibility of isolating subjects with single genetic variants, it is not possible to directly map the genetic interaction networks in humans. Researchers hope that learning about the characteristics of genetic interaction networks in suitable organisms will provide tools for constructing the genetic interaction network of humans.[1]
^ abcCite error: The named reference Baryshnikova2013 was invoked but never defined (see the help page).
and 26 Related for: Genetic interaction network information
Geneticinteractionnetworks represent the functional interactions between pairs of genes in an organism and are useful for understanding the relation...
minimally complex networks. Quantitative genetics focuses on genetic variance due to geneticinteractions. Any two locus interactions at a particular gene...
A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell...
Synthetic genetic array analysis (SGA) is a high-throughput technique for exploring synthetic lethal and synthetic sick geneticinteractions (SSL). SGA...
for Interaction Datasets (BioGRID) is a curated biological database of protein-protein interactions, geneticinteractions, chemical interactions, and...
In computer science and operations research, a genetic algorithm (GA) is a metaheuristic inspired by the process of natural selection that belongs to...
Genetics is the study of genes, genetic variation, and heredity in organisms. It is an important branch in biology because heredity is vital to organisms'...
In micro-sociology, interactionism is a theoretical perspective that sees social behavior as an interactive product of the individual and the situation...
University of Toronto create the first map that shows the global geneticinteractionnetwork of a cell. It begins to explain how thousands of genes coordinate...
Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology...
implications for the demographic and genetic structure of plant populations, as well as migration patterns and species interactions. There are five main modes of...
to a geneticinteraction in which a cell that is nonviable, sensitive to a specific drug, or otherwise impaired due to the presence of a genetic mutation...
Thompson J, Roemer T (November 2011). "Antagonism of chemical geneticinteractionnetworks resensitize MRSA to β-lactam antibiotics". Chemistry & Biology...
Genetic counseling is the process of investigating individuals and families affected by or at risk of genetic disorders to help them understand and adapt...
therefore describe the daughter languages within a language family as being genetically related. The divergence of a proto-language into daughter languages typically...
unfavorable) that arise from an interaction between the medication and/or its metabolites and a site other than the intended target. Genetic variation in the off-target...
A biological network is a method of representing systems as complex sets of binary interactions or relations between various biological entities. In general...
Biomolecular Object Network Databank is a bioinformatics databank containing information on small molecule structures and interactions. The databank integrates...
nature and strength of these interactions between species, DNA, proteins, and more. The analysis of biological networks with respect to diseases has led...
among organisms. Developmental biologists suggest that complex interactions in geneticnetworks and communication among cells can lead to heritable variations...
Global Information