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GeneNetwork
Developer(s)
GeneNetwork Development Team, University of Tennessee
Initial release
15 January 1994; 30 years ago (1994-01-15)
Stable release
2.0
/ 29 May 2016; 8 years ago (2016-05-29)
Repository
github.com/genenetwork/genenetwork2
Written in
JavaScript, HTML, Python, CSS, CoffeeScript, PHP
License
Affero General Public License
Website
www.genenetwork.org
GeneNetwork is a combined database and open-source bioinformatics data analysis software resource for systems genetics.[1] This resource is used to study gene regulatory networks that link DNA sequence differences to corresponding differences in gene and protein expression and to variation in traits such as health and disease risk. Data sets in GeneNetwork are typically made up of large collections of genotypes (e.g., SNPs) and phenotypes from groups of individuals, including humans, strains of mice and rats, and organisms as diverse as Drosophila melanogaster, Arabidopsis thaliana, and barley.[2] The inclusion of genotypes makes it practical to carry out web-based gene mapping to discover those regions of genomes that contribute to differences among individuals in mRNA, protein, and metabolite levels, as well as differences in cell function, anatomy, physiology, and behavior.
^Morahan, G; Williams, RW (2007). "Systems Genetics: The Next Generation in Genetics Research?". Decoding the Genomic Control of Immune Reactions. Novartis Foundation Symposia. Vol. 281. pp. 181–8, discussion 188–91, 208–9. doi:10.1002/9780470062128.ch15. ISBN 9780470062128. PMID 17534074. {{cite book}}: |journal= ignored (help)
^Druka, A; Druka, I; Centeno, AG; Li, H; Sun, Z; Thomas, WT; Bonar, N; Steffenson, BJ; Ullrich, SE; Kleinhofs, Andris; Wise, Roger P; Close, Timothy J; Potokina, Elena; Luo, Zewei; Wagner, Carola; Schweizer, Günther F; Marshall, David F; Kearsey, Michael J; Williams, Robert W; Waugh, Robbie (2008). "Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork". BMC Genetics. 9: 73. doi:10.1186/1471-2156-9-73. PMC 2630324. PMID 19017390.
GeneNetwork is a combined database and open-source bioinformatics data analysis software resource for systems genetics. This resource is used to study...
represent genes, transcripts, or proteins and edges connecting these nodes represent the strength of association (see GeneNetworkGeneNetwork 2). The following...
database) FishBase Flags of the World Flora Europaea Gallica GameRankings GeneNetwork GeoNames Gesamtkatalog der Wiegendrucke Getty Thesaurus of Geographic...
transcription factors to infer their downstream genenetworks. Orthology methods transfer genenetwork knowledge from one species to another. Literature...
custom code such as QTL Reaper or the web-based eQTL mapping system GeneNetwork. GeneNetwork hosts many large eQTL mapping data sets and provide access to fast...
The Network of Cancer Genes (NCG) is a freely accessible web resource of genes that, when altered in their sequence, drive clonal expansion of normal tissues...
effect of a gene mutation is dependent on the presence or absence of mutations in one or more other genes, respectively termed modifier genes. In other...
word gene (Greek: γένος, génos; generation, or birth, or gender) has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is...
2021 paper has ascribed this phenomenon to perturbations of floral genenetworks that causes the development of meristems into flowers to fail, but instead...
strongly with other genes and was part of a gene regulatory network, the derived mutation that is unique to the modern human version of the gene knocked out the...
plants. Homeotic genes often encode transcription factor proteins, and these proteins affect development by regulating downstream genenetworks involved in...
theory of complex gene regulatory networks using statistical mechanics. In its simplest form, Goodwin's oscillator involves a single gene that represses...
Trait Consortium A Statistical Framework for Quantitative Trait Mapping GeneNetwork GridQTL QTL discussion forum A list of computer programs for genetic...
transcriptional regulatory network. A gene co-expression network is an undirected graph, where each node corresponds to a gene, and a pair of nodes is connected...
Weighted correlation network analysis, also known as weighted gene co-expression network analysis (WGCNA), is a widely used data mining method especially...
interactions (Systems Biology). Led by Nicolas Le Novère. Neurogenetics GeneNetworkGenenetwork started as component of the NIH Human Brain Project in 1999 with...
expected in random networks. This idea was further generalized in 2002 by Uri Alon and his group when network motifs were discovered in the gene regulation (transcription)...
Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals...
expression and genenetwork information. It has also improved the speed and sophistication of the search engine, and expanded from a gene-centric dogma...
Complexes PRC1 and PRC2 function in the silencing of expression of the Hox genenetwork involved in development as well as the inactivation of the X chromosome...
subsystems (such as the networks of metabolites and enzymes that comprise metabolism, signal transduction pathways and gene regulatory networks) to both analyze...
is a biosimulation company based in Somerville, MA. A company called GeneNetwork Sciences (GNS) was founded in 2000 by Cornell physicists Colin Hill and...
Gene Rayburn (born Eugene Peter Jeljenic; December 22, 1917 – November 29, 1999) was an American radio and television personality. He is best known as...
molecular biology, a reporter gene (often simply reporter) is a gene that researchers attach to a regulatory sequence of another gene of interest in bacteria...
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