Gasotransmitters is a class of neurotransmitters. The molecules are distinguished from other bioactive endogenous gaseous signaling molecules based on a need to meet distinct characterization criteria. Currently, only nitric oxide, carbon monoxide, and hydrogen sulfide are accepted as gasotransmitters.[1] According to in vitro models, gasotransmitters, like other gaseous signaling molecules, may bind to gasoreceptors and trigger signaling in the cells.[1]
The name gasotransmitter is not intended to suggest a gaseous physical state such as infinitesimally small gas bubbles; the physical state is dissolution in complex body fluids and cytosol.[2] These particular gases share many common features in their production and function but carry on their tasks in unique ways which differ from classical signaling molecules.
^ abMustafa AK, Gadalla MM, Snyder SH (April 2009). "Signaling by gasotransmitters". Science Signaling. 2 (68): re2. doi:10.1126/scisignal.268re2. PMC 2744355. PMID 19401594.
^Simpson PV, Schatzschneider U (2014-04-18). "Release of Bioactive Molecules Using Metal Complexes". In Gasser G (ed.). Inorganic Chemical Biology. Chichester, UK: John Wiley & Sons, Ltd. pp. 309–339. doi:10.1002/9781118682975.ch10. ISBN 978-1-118-68297-5.
Gasotransmitters is a class of neurotransmitters. The molecules are distinguished from other bioactive endogenous gaseous signaling molecules based on...
phenylpyruvic acid are endogenous sources for carbon monoxide (as a gasotransmitter) and pharmaceutical prodrug scaffold. Important representatives: pyruvic...
where low concentrations serve as an endogenous neurotransmitter (gasotransmitter) and high concentrations are toxic resulting in carbon monoxide poisoning...
to mean, bisulfide. Hydrosulfide has been identified as the third gasotransmitter along with nitric oxide and carbon monoxide. SH− is a soft anionic...
it can serve as an important neurotransmitter (subcategorized as a gasotransmitter) and a potential therapeutic agent. In the case of prokaryotes, some...
actively investigated, due to the importance of carbon monoxide as a gasotransmitter. Within the realm of bioorganometallic chemistry is the study of the...
it has essential roles as a neurotransmitter (subcategorized as a gasotransmitter). The majority of endogenous carbon monoxide is produced by heme oxygenase;...
a neurotransmitter in 1993 and has since been subcategorized as a gasotransmitter. Most endogenously produced carbon monoxide is stored as carboxyhemoglobin...
colonic and ileal smooth muscle and a possible role for methane as a gasotransmitter. Statins can inhibit archaeal cell membrane biosynthesis apparently...
biologic systems (cells), these gaseous molecules are referred to as gasotransmitters. Because of their diverse biological functions and widespread abundance...
outlined below. Gasotransmitters are a class of neurotransmitters. Only three gases are accepted to be classified as gasotransmitters including nitric...
hydrogen sulfide. Hydrogen sulfide (H2S) works as a vasculoprotective gasotransmitter in the human body but is also tested to reduced intimal hyperplasia...
BK channels can be activated by exogenous pollutants and endogenous gasotransmitters carbon monoxide, nitric oxide, and hydrogen sulphide. Mutations in...
Rahman MA, Reddy D, et al. (September 2016). "The emerging role of gasotransmitters in the pathogenesis of tuberculosis". Nitric Oxide. 59: 28–41. doi:10...
for which some other PHD-inhibitors show overlapping specificity. Gasotransmitters including carbon monoxide and nitric oxide are also inhibitors of PHD2...
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