Calcium-activated BK potassium channel alpha subunit
Identifiers
Symbol
BK_channel_a
Pfam
PF03493
InterPro
IPR003929
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
BK channels (big potassium), are large conductance calcium-activated potassium channels,[1] also known as Maxi-K, slo1, or Kca1.1. BK channels are voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane, hence their name, big potassium. These channels can be activated (opened) by either electrical means, or by increasing Ca2+ concentrations in the cell.[2][3] BK channels help regulate physiological processes, such as circadian behavioral rhythms and neuronal excitability.[4] BK channels are also involved in many processes in the body, as it is a ubiquitous channel. They have a tetrameric structure that is composed of a transmembrane domain, voltage sensing domain, potassium channel domain, and a cytoplasmic C-terminal domain, with many X-ray structures for reference. Their function is to repolarize the membrane potential by allowing for potassium to flow outward, in response to a depolarization or increase in calcium levels.
^Zang K, Zhang Y, Hu J, Wang Y (2018). "The Large Conductance Calcium- and Voltage-activated Potassium Channel (BK) and Epilepsy". CNS & Neurological Disorders Drug Targets. 17 (4): 248–254. doi:10.2174/1871527317666180404104055. PMID 29623857. S2CID 4663325.
^Miller, C. (2000). Genome Biology, 1(4), reviews0004.1. https://dx.doi.org/10.1186/gb-2000-1-4-reviews0004
^Yuan, P., Leonetti, M., Pico, A., Hsiung, Y., & MacKinnon, R. (2010). Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution. Science, 329(5988), 182-186. https://dx.doi.org/10.1126/science.1190414
^N'Gouemo P (November 2011). "Targeting BK (big potassium) channels in epilepsy". Expert Opinion on Therapeutic Targets. 15 (11): 1283–95. doi:10.1517/14728222.2011.620607. PMC 3219529. PMID 21923633.
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