Transvaginal ultrasonography showing a foreign body granuloma at right as a hypoechoic (dark) area around a perforated intrauterine device. The uterus is at left.
Specialty
Dermatology
A foreign body reaction (FBR) is a typical tissue response to a foreign body within biological tissue.[1] It usually includes the formation of a foreign body granuloma.[2] Tissue-encapsulation of an implant is an example, as is inflammation around a splinter.[3] Foreign body granuloma formation consists of protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis. It has also been proposed that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response.[4]
In the long term, the foreign body reaction results in encapsulation of the foreign body within a calcified shell. For example, a lithopedion is a rare phenomenon which occurs most commonly when a fetus dies during an abdominal pregnancy,[5] is too large to be reabsorbed by the body, and calcifies.
^Harlim, Ago; Kanoko, Mpu; Aisah, Siti (2018). "Classification of Foreign Body Reactions due to Industrial Silicone Injection". Dermatologic Surgery. 44 (9): 1174–1182. doi:10.1097/DSS.0000000000001531. ISSN 1076-0512. PMC 6112849. PMID 29757858.
^Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1443. ISBN 978-1-4160-2999-1.
^Biomaterials Science Second edition, Ratner et al. Pp. 296-304
^Hilborn, Jöns; Bjursten, Lars M. (March 2007). "A new and evolving paradigm for biocompatibility". Journal of Tissue Engineering and Regenerative Medicine. 1 (2): 110–119. doi:10.1002/term.4. ISSN 1932-6254. PMID 18038399. S2CID 44559859.
^Spitz, Werner U.; Spitz, Daniel J., eds. (2006). "Chapter III: Time of Death and Changes after Death. Part 1: Anatomical Considerations.". Spitz and Fisher's medicolegal investigation of death : guidelines for the application of pathology to crime investigation (4th ed.). Springfield, Ill.: Charles C. Thomas. pp. 87–127. ISBN 0398075441. OCLC 56614481.
and 24 Related for: Foreign body reaction information
foreignbodyreaction (FBR) is a typical tissue response to a foreignbody within biological tissue. It usually includes the formation of a foreign body...
A foreignbody (FB) is any object originating outside the body of an organism. In machinery, it can mean any unwanted intruding object. Most references...
infection, such as tuberculosis, herpes, or HIV, or as part of a foreignbodyreaction. These MGCs are cells of monocyte or macrophage lineage fused together...
synthetic biomaterials are considered foreign by the innate immune system. This can lead to a foreignbodyreaction when implanted. Products made from medical...
large to be reabsorbed by the body, and calcifies on the outside as part of a foreignbodyreaction, shielding the mother's body from the dead tissue of the...
Foreignbody aspiration occurs when a foreignbody enters the airway which can cause difficulty breathing or choking. Objects may reach the respiratory...
leave behind a foreignbodyreaction or fibrotic adhesions. However, peritonitis may also be caused by the rare case of a sterile foreignbody inadvertently...
injection (Silicone-induced granulomatous inflammation) or other foreignbodyreactions. Idiopathic granulomatous mastitis (IGM) is defined as granulomatous...
depend for contraception on the general reaction of the uterus to a foreignbody. It is believed that this reaction, a sterile inflammatory response, produces...
allergic reactions to materials used in dental restorations, specific toothpastes, mouthwashes, and even some foods. Trauma, reactions to foreignbodies, or...
completely reabsorbed in 6 months and can be seen only a minimal foreignbodyreaction tissue in the vicinity of the implant. Materials made of PDS can...
biocompatibility ranges from how easily it is integrated to how severe the foreignbodyreaction is. A minimal response includes the formation of fibrosis around...
involving PMMA windshield material did not show any rejection or foreignbodyreaction, and deduced that the transparent material was inert and useful...
with a permanent synthetic mesh, including chronic inflammation, foreignbodyreaction, fibrosis, and mesh infection." As of 2015[update], however, the...
One of the most common locations for a foreignbody is the alimentary tract. It is possible for foreignbodies to enter the tract either from the mouth...
PLLA is used to stimulate collagen synthesis in fibroblasts via foreignbodyreaction in the presence of macrophages. Macrophages act as a stimulant in...
fillers. In certain cases, the filler results in a granulomatous foreignbodyreaction. Even though side effects are rare Restylane should not be used...
will have a reaction when in contact with the human body. The success of a biomaterial relies on the host tissue's reaction with the foreign material. Specific...
usually of lesser concern. If left embedded, the mouthparts cause a foreignbodyreaction and are usually eventually sloughed like a splinter. It has been...
rigidity and brittleness. Once ruptured, the exposed pigments cause a foreignbodyreaction and inflammation. This pigment deposition also invokes deposition...
presentation. Therefore, more common skin conditions, like cellulitis, foreignbodyreaction, skin cancer, and fungal or parasitic infections, are often explored...
some cases, hyaluronic acid fillers can result in a granulomatous foreignbodyreaction. Hyaluronic acid is used to displace tissues away from tissues which...
Trindade R, Albrektsson T, Tengvall P, Wennerberg A (February 2016). "ForeignBodyReaction to Biomaterials: On Mechanisms for Buildup and Breakdown of Osseointegration"...
Global Information
