Flavr Savr (also known as CGN-89564-2; pronounced "flavor saver"), a genetically modified tomato, was the first commercially grown genetically engineered food to be granted a license for human consumption. It was developed by the Californian company Calgene in the 1980s.[1] The tomato has an improved shelf-life, increased fungal resistance and a slightly increased viscosity compared to its non-modified counterpart.[2] It was meant to be harvested ripe for increased flavor for long-distance shipping.[1] The Flavr Savr contains two genes added by Calgene; a reversed antisense polygalacturonase gene which inhibits the production of a rotting enzyme and a gene responsible for the creation of APH(3')II,[3] which confers resistance to certain aminoglycoside antibiotics including kanamycin and neomycin.[4] On May 18, 1994,[5] the FDA completed its evaluation of the Flavr Savr tomato and the use of APH(3')II, concluding that the tomato "is as safe as tomatoes bred by conventional means" and "that the use of aminoglycoside 3'-phosphotransferase II is safe for use as a processing aid in the development of new varieties of tomato, rapeseed oil, and cotton intended for food use." It was first sold in 1994, and was only available for a few years before production ceased in 1997.[6] Calgene made history, but mounting costs prevented the company from becoming profitable,[7] and it was eventually acquired by Monsanto Company.[1]
^ abc"Transcript: GMO Food Fears and the First Test Tube Tomato". Retro Report. June 24, 2013. Archived from the original on March 6, 2022. Retrieved March 6, 2022.
^Redenbaugh, Keith; Bill Hiatt; Belinda Martineau; Matthew Kramer; Ray Sheehy; Rick Sanders; Cathy Houck; Don Emlay (1992). Safety Assessment of Genetically Engineered Fruits and Vegetables: A Case Study of the Flavr Savr Tomato. CRC Press. p. 288.
^"Agency Summary Memorandum Re: Consultation with Calgene Inc., Concerning Flavr Savr™ Tomatoes". FDA. May 17, 1994. Archived from the original on January 24, 2018. Retrieved February 17, 2022.
^"Code of Federal Regulations". govinfo.gov. May 1, 2009. Retrieved March 6, 2022.
^Stone, Brad. "The Flavr Savr Arrives". Retrieved December 29, 2012.
^Weasel, Lisa H. 2009. Food Fray. Amacom Publishing
^Cite error: The named reference :2 was invoked but never defined (see the help page).
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