Flavin containing monooxygenase 1 information

FMO1
Identifiers
Aliases	FMO1, flavin containing monooxygenase 1, flavin containing dimethylaniline monoxygenase 1
External IDs	OMIM: 136130; MGI: 1310002; HomoloGene: 55520; GeneCards: FMO1; OMA:FMO1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	171,285,978 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	162,694,179 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; mucosa of ileum; ; parietal pleura; ; mucosa of paranasal sinus; ; renal medulla; ; oral cavity; ; skin of thigh;
	Top expressed in
	right kidney; ; human kidney; ; yolk sac; ; gastrula; ; proximal tubule; ; right lung; ; tunica adventitia of aorta; ; brown adipose tissue; ; right lung lobe; ; cardiac muscle tissue of left ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding; monooxygenase activity; protein binding;
Cellular component	organelle membrane; integral component of membrane; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle;
Biological process	response to osmotic stress; xenobiotic metabolic process; toxin metabolic process; response to lipopolysaccharide; NADPH oxidation; organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2326
	14261
	ENSG00000010932
	ENSMUSG00000040181
	Q01740
	P50285
	NM_001282692; NM_001282693; NM_001282694; NM_002021
	NM_010231; NM_001330291; NM_001330318
	NP_001269621; NP_001269622; NP_001269623; NP_002012
	NP_001317220; NP_001317247; NP_034361
	Wikidata
View/Edit Human	View/Edit Mouse

Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene.^[5]

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in xenobiotics such as pesticides and drugs.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000010932 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040181 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: FMO1 flavin containing monooxygenase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000010932 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040181 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FMO1 flavin containing monooxygenase 1".

Flavin containing monooxygenase 1 information

and 18 Related for: Flavin containing monooxygenase 1 information

Flavin containing monooxygenase 1

Flavin

Flavin adenine dinucleotide

Monoamine oxidase

Phenylacetone

Squalene monooxygenase

Vandetanib

Riboflavin

FMO5

Tyramine

Flavin reductase

Trimethylaminuria

Nitronate monooxygenase

Chromosome 1

FMO2

Luciferase

FMO4

Cyclohexanone monooxygenase