Trimethylaminuria (TMAU), also known as fish odor syndrome or fish malodor syndrome,[1] is a rare metabolic disorder that causes a defect in the normal production of an enzyme named flavin-containing monooxygenase 3 (FMO3).[2][3] When FMO3 is not working correctly or if not enough enzyme is produced, the body loses the ability to properly convert the fishy-smelling chemical trimethylamine (TMA) from precursor compounds in food digestion into trimethylamine oxide (TMAO), through a process called N-oxidation.
Trimethylamine then builds up and is released in the person's sweat, urine, and breath, giving off a fishy odor. Primary trimethylaminuria is caused by genetic mutations that affect the FMO3 function of the liver. Symptoms matching TMAU can also occur when there is no genetic cause, yet excessive TMA is excreted - this has been described as secondary trimethylaminuria (TMAU2).
^Mitchell SC, Smith RL (2001). "Trimethylaminuria: the fish malodor syndrome". Drug Metab Dispos. 29 (4 Pt 2): 517–21. PMID 11259343.
^Treacy EP, et al. (1998). "Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication". Human Molecular Genetics. 7 (5): 839–45. doi:10.1093/hmg/7.5.839. PMID 9536088.
^Zschocke J, Kohlmueller D, Quak E, Meissner T, Hoffmann GF, Mayatepek E (1999). "Mild trimethylaminuria caused by common variants in FMO3 gene". Lancet. 354 (9181): 834–5. doi:10.1016/S0140-6736(99)80019-1. PMID 10485731. S2CID 9555588.
Trimethylaminuria (TMAU), also known as fish odor syndrome or fish malodor syndrome, is a rare metabolic disorder that causes a defect in the normal production...
trimethylamine in the body are associated with the development of trimethylaminuria, or fish odor syndrome, caused by a genetic defect in the enzyme which...
objective noninvasive measure of liver failure. A secondary form of trimethylaminuria is also associated with liver failure, and it has been suggested that...
original (PDF) on 2016-03-03. Retrieved 2015-02-23. "Learning About Trimethylaminuria". genome.gov. National Human Genome Research Institute. Kaufmann,...
original (PDF) on 2016-03-03. Retrieved 2017-02-19. "Learning About Trimethylaminuria". genome.gov. National Human Genome Research Institute. Bowen, R....
original (PDF) on 2016-03-03. Retrieved 2012-03-03. "Learning About Trimethylaminuria". genome.gov. National Human Genome Research Institute. Kaufmann,...
(TMA) formed by the gut microbes from the unabsorbed choline (see trimethylaminuria). The liver oxidizes TMA to trimethylamine N-oxide (TMAO). Elevated...
dramedy Freaks and Geeks as Gordon Crisp, an optimistic geek with trimethylaminuria. He also appeared in five episodes of Even Stevens and two episodes...
reporting idiopathic malodor production: demographics and incidence of trimethylaminuria". The American Journal of Medicine. 124 (11): 1058–63. doi:10.1016/j...
clean clothes is also very important especially if you sweat a lot. Trimethylaminuria (TMAU), also known as fish odor syndrome or fish malodor syndrome...
pterygium syndrome prostate cancer Stickler syndrome TAR syndrome trimethylaminuria Usher syndrome Usher syndrome type II Van der Woude syndrome Variegate...
L-carnitine) from normal diet, from which seems originate two diseases, trimethylaminuria (or Fish-Odor Syndrome) and cardiovascular disease through the proatherogenic...
L-carnitine) from normal diet, from which seems originate two diseases, trimethylaminuria (or Fish-Odor Syndrome) and cardiovascular disease through the proatherogenic...
geeks. Despite being overweight and having chronic body odour from trimethylaminuria, Gordon tends to be optimistic and take things in stride. Gordon was...
diseases are already defined and known to cause Bromhidrosis symptoms: Trimethylaminuria Dimethyglycineuria Defects in SELENBP1 gene which leads to accumulation...
reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found...
reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found...
revealed a large, undiagnosed population of people suffering from trimethylaminuria, an odor-producing genetic disorder. Preti’s work has frequently been...
reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found...
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