Fetal fibronectin (fFN) is a fibronectin protein produced by fetal cells. It is found at the interface of the chorion and the decidua (between the fetal sac and the uterine lining). Fetal fibronectin is found normally in vaginal fluid in early pregnancy prior to 22 weeks due to normal growth and development of tissues at the junction of the uterus and amniotic sac. It may also be found in vaginal fluid after 36 weeks as labor approaches. However, fFN should not be detected between 22 and 36 weeks.[1]
It can be thought of as an adhesive or "biological glue" that binds the fetal sac to the uterine lining.[2] It is the product of alternative splicing of the fibronectin gene and contains a oncofetal domain not present in adult fibronectin.[3]
^Berghella V, Saccone G (July 2019). "Fetal fibronectin testing for reducing the risk of preterm birth". The Cochrane Database of Systematic Reviews. 7 (7): CD006843. doi:10.1002/14651858.CD006843.pub3. PMC 6663121. PMID 31356681.
^"Fetal fibronectin test". Mayo Clinic. Retrieved 19 March 2016.
^Patten J, Wang K (March 2021). "Fibronectin in development and wound healing". Advanced Drug Delivery Reviews. 170: 353–368 (357). doi:10.1016/j.addr.2020.09.005. PMID 32961203.
Fetalfibronectin (fFN) is a fibronectin protein produced by fetal cells. It is found at the interface of the chorion and the decidua (between the fetal...
sulfate. Fibronectin has been shown to interact with: CD44 COL7A1, LPA, IGFBP3, TNC, and TRIB3. FetalfibronectinFibronectin type I domain Fibronectin type...
suggestive of preterm labor. In one investigation comparing this test to fetalfibronectin testing and cervical length measurement via transvaginal ultrasound...
cervical-vaginal fetalfibronectin concentration. Pathophysiology of the fetal membranes, such as microfractures, senescence of cells in the fetal membrane and...
amongst other risk factors including the presence of cervicovaginal fetalfibronectin (fFN). Metronidazole was ineffective in preventing preterm delivery...
Fetal bovine serum (FBS) is derived from the blood drawn from a bovine fetus via a closed system of collection at the slaughterhouse. Fetal bovine serum...
premature (prelabor) rupture of membranes List of obstetric topics Fetalfibronectin (fFN) Apgar score Bishop, Edward H. (August 1964). "Pelvic Scoring...
Fédération Française de Natation, the French Swimming Federation Fetalfibronectin Free French Navy Friend Finder Networks, a social media website Full...
viewed under a microscope. Fibronectin and alpha-fetoprotein blood tests Prelabor rupture of membranes (PROM): when the fetal membranes rupture early, at...
the ECM differ in fetal and adult wound healing. This is due to the early up regulation of cell adhesion proteins such as fibronectin and tenascin in the...
components of the extracellular matrix, including proteoglycans, laminin, and fibronectin, which are found in the cervical stroma (parametrium). Third, due to...
Fibrin and fibronectin cross-link together and form a plug that traps proteins and particles and prevents further blood loss. This fibrin-fibronectin plug is...
Rachel M.Tribe, Andrew H.Shennan (2013) Evaluation of a quantitative fetalfibronectin test for spontaneous preterm birth in symptomatic women. American...
maternal blood to come into direct contact with the fetal chorion, a membrane between the fetal and maternal tissues, and allows for nutrient and gas...
that associate with extracellular matrix proteins, including collagen, fibronectin, and laminin, during migration. Once the basal lamina becomes permeable...
osmolyte and carrier protein α-fetoprotein, the fetal counterpart of serum albumin Soluble plasma fibronectin, forming a blood clot that stops bleeding C-reactive...
decidual cells, which create a pericellular extracellular matrix rich in fibronectin and laminin (similar to epithelial cells). Vascularity, as well as vascular...
propria is composed of ground substances such as hyaluronic acid and fibronectin, fibroblasts, elastic fibers, and collagenous fibers. While the fibrous...
peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain. Proteins...
networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. The proteins also bind to cell membranes through integrins...
the placental are epithelial, mesenchymal markers like vimentin and fibronectin can also be used for identification. These markers, however, are not...
fetuses leading to fetal alcohol syndrome has been shown to be dependent on antioxidant levels in the brain such as vitamin E. As the fetal brain is relatively...
Plasmin is also integrally involved in inflammation. It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin, like trypsin...
Global Information