FANCM information

Search for
Structures	Swiss-model
Domains	InterPro

Fanconi anemia, complementation group M
Fanconi anemia, complementation group M
Identifiers
Symbol	FANCM
Alt. symbols	KIAA1596
NCBI gene	57697
HGNC	23168
OMIM	609644
PDB	4BXO
RefSeq	XM_048128
UniProt	Q8IYD8
Other data
EC number	3.6.1.-
Locus	Chr. 14 q21.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

FANCM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BXO, 4DAY, 4DRB, 4E45, 4M6W
Identifiers
Aliases	FANCM, FAAP250, KIAA1596, Fanconi anemia complementation group M, FA complementation group M, POF15, SPGF28
External IDs	OMIM: 609644; MGI: 2442306; HomoloGene: 35378; GeneCards: FANCM; OMA:FANCM - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	45,200,890 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	65,178,832 bp
RNA expression pattern
	Top expressed in
	sperm; ; oocyte; ; testicle; ; secondary oocyte; ; ventricular zone; ; gonad; ; right testis; ; left testis; ; Achilles tendon; ; ganglionic eminence;
	Top expressed in
	tail of embryo; ; blastocyst; ; genital tubercle; ; morula; ; morula; ; zygote; ; secondary oocyte; ; epiblast; ; ventricular zone; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nuclease activity; nucleotide binding; chromatin binding; protein binding; ATP binding; hydrolase activity; helicase activity; 3'-5' DNA helicase activity;
Cellular component	FANCM-MHF complex; Fanconi anaemia nuclear complex; nucleus; nucleoplasm;
Biological process	resolution of meiotic recombination intermediates; interstrand cross-link repair; replication fork processing; nucleic acid phosphodiester bond hydrolysis; cellular response to DNA damage stimulus; DNA repair; DNA duplex unwinding; positive regulation of protein monoubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	57697
	104806
	ENSG00000187790
	ENSMUSG00000055884
	Q8IYD8
	Q8BGE5
	NM_001308133; NM_001308134; NM_020937
	NM_178912; NM_001364447
	NP_001295062; NP_001295063; NP_065988
	NP_849243; NP_001351376
	Wikidata
View/Edit Human	View/Edit Mouse

Fanconi anemia, complementation group M, also known as FANCM is a human gene.^[5]^[6] It is an emerging target in cancer therapy, in particular cancers with specific genetic deficiencies.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187790 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055884 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
^ Meetei AR, Medhurst AL, Ling C, Xue Y, Singh TR, Bier P, et al. (September 2005). "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M". Nature Genetics. 37 (9): 958–63. doi:10.1038/ng1626. PMC 2704909. PMID 16116422.
^ Pan X, Ahmed N, Kong J, Zhang D (2017-11-02). "Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy". Molecular & Cellular Oncology. 4 (6): e1360978. doi:10.1080/23723556.2017.1360978. PMC 5706943. PMID 29209649.
^ O'Rourke JJ, Bythell-Douglas R, Dunn EA, Deans AJ (October 2019). "ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres". Nucleus. 10 (1): 221–230. doi:10.1080/19491034.2019.1685246. PMC 6949022. PMID 31663812.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187790 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055884 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10997877-5] Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.

[pmid16116422-6] Meetei AR, Medhurst AL, Ling C, Xue Y, Singh TR, Bier P, et al. (September 2005). "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M". Nature Genetics. 37 (9): 958–63. doi:10.1038/ng1626. PMC 2704909. PMID 16116422.

[7] Pan X, Ahmed N, Kong J, Zhang D (2017-11-02). "Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy". Molecular & Cellular Oncology. 4 (6): e1360978. doi:10.1080/23723556.2017.1360978. PMC 5706943. PMID 29209649.

[O'Rourke_2019-8] O'Rourke JJ, Bythell-Douglas R, Dunn EA, Deans AJ (October 2019). "ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres". Nucleus. 10 (1): 221–230. doi:10.1080/19491034.2019.1685246. PMC 6949022. PMID 31663812.

FANCM information

and 24 Related for: FANCM information

FANCM

Chromosomal crossover

Fanconi anemia

Helicase

List of genetic disorders

FANCD2

Alternative Lengthening of Telomeres

Bloom syndrome

Xenopus

BRCA2

PALB2

Bloom syndrome protein

FANC proteins

Chromothripsis

Hereditary cancer syndrome

RMI1

RecQ helicase

TOP3A

Chromatin bridge

FANCL

FANCG

FANCI

Simon Boulton

FANCA