FANCL information

FANCL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZQS, 4CCG
Identifiers
Aliases	FANCL, FAAP43, PHF9, POG, Fanconi anemia complementation group L, FA complementation group L
External IDs	OMIM: 608111; MGI: 1914280; HomoloGene: 9987; GeneCards: FANCL; OMA:FANCL - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	58,241,410 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	26,421,876 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; Achilles tendon; ; corpus callosum; ; tibia; ; secondary oocyte; ; right uterine tube; ; pons; ; embryo; ; body of pancreas;
	Top expressed in
	Paneth cell; ; primitive streak; ; abdominal wall; ; endocardial cushion; ; maxillary prominence; ; interventricular septum; ; fossa; ; medial ganglionic eminence; ; atrioventricular valve; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; metal ion binding; ubiquitin protein ligase binding; ubiquitin protein ligase activity; transferase activity;
Cellular component	cytoplasm; nucleus; nuclear envelope; Fanconi anaemia nuclear complex; nucleoplasm; nuclear body; intracellular membrane-bounded organelle;
Biological process	protein ubiquitination; gamete generation; regulation of cell population proliferation; interstrand cross-link repair; protein monoubiquitination; cellular response to DNA damage stimulus; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	55120
	67030
	ENSG00000115392
	ENSMUSG00000004018
	Q9NW38
	Q9CR14
	NM_001114636; NM_018062; NM_001374615
	NM_001277273; NM_025923
	NP_001108108; NP_060532; NP_001361544
	NP_001264202; NP_080199
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115392 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004018 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FANCL Fanconi anemia, complementation group L".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115392 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004018 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FANCL Fanconi anemia, complementation group L".

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