Substance formulated alongside the active ingredient of a medication
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Excipient is a substance formulated alongside the active ingredient of a medication. Excipients serve various purposes, including long-term stabilization, bulking up solid formulations containing potent active ingredients in small amounts (often referred to as "bulking agents", "fillers", or "diluents"), or enhancing the therapeutic properties of the active ingredient in the final dosage form. They can facilitate drug absorption, reduce viscosity, or enhance solubility.[1][2] Excipients can also aid in the manufacturing process by improving the handling of active substances, facilitating powder flowability, or preventing denaturation and aggregation during the expected shelf life. The selection of excipients depends on factors such as the route of administration, dosage form, and active ingredient.
Pharmaceutical regulations and standards mandate the identification and safety assessment of all ingredients in drugs, including their chemical decomposition products. It is common for a final drug formulation to contain more excipient than active ingredient, and virtually all marketed drugs contain excipients. In some cases, novel excipients can be patented, while in others, the specific formulation involving them is kept as a trade secret to prevent reverse engineering.[citation needed]
^Borbás E, Sinkó B, Tsinman O, Tsinman K, Kiserdei É, Démuth B, et al. (November 2016). "Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions". Molecular Pharmaceutics. 13 (11): 3816–3826. doi:10.1021/acs.molpharmaceut.6b00613. PMID 27611057.
^Hsu T, Mitragotri S (September 2011). "Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer". Proceedings of the National Academy of Sciences of the United States of America. 108 (38): 15816–21. Bibcode:2011PNAS..10815816H. doi:10.1073/pnas.1016152108. PMC 3179050. PMID 21903933.
Excipient is a substance formulated alongside the active ingredient of a medication. Excipients serve various purposes, including long-term stabilization...
semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety...
Generally it is only recommended for up to two weeks. It is also used as an excipient. It is also used to clear the bowels (known as "bowel prep") before a...
of oral and topical pharmaceutical products. Polysorbate 80 is also an excipient that is used to stabilize aqueous formulations of medications for parenteral...
cellulose has been documented. It has been noted as a potential MCAS excipient trigger depending on the source and processing method of the cellulose...
This is a list of excipients per vaccine, as published by the United States Centers for Disease Control. Vaccine ingredients and production in other nations...
are formed from a mixture of gelator, solvent, active drug, and other excipients, and can be classified into organogels and hydrogels. Drug formulation...
present in many asthma and whooping cough drugs. It is also used as an excipient in some testosterone-replacement medications (like Nebido) for treating...
for preserving food and beverages. Sodium metabisulfite is added as an excipient to medications which contain adrenaline (epinephrine), in order to prevent...
cellulose with both water solubility and organic solubility. It is used as an excipient, and topical ophthalmic protectant and lubricant. HPC is an ether of cellulose...
the inactive ingredients are usually called excipients in pharmaceutical contexts. The main excipient that serves as a medium for conveying the active...
glucose that contains an amino group modification. It is often used as an excipient in pharmaceuticals and in conjunction with iodinated compounds in contrast...
as an excipient (Cationorm, Retaine MGD) or as an active ingredient (Bonjela, Pansoral). It may be found in very small amount in the excipient benzalkonium...
multiple names: authors list (link) Media related to Pharmaceutics at Wikimedia Commons Excipient selection for injectable / parenteral formulations v t e...
expressed as H−(O−CH2−CH2)n−OH. Pharmaceutical-grade PEG is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage...
because of causing contact dermatitis. When used as a pharmaceutical excipient, after oral administration its bioavailability is about 0.34, due to a...
Pharmaceutical Excipients Council is a global organization founded in 1991 representing producers, suppliers, and end users of excipients. The body has...
Sugar is the generic name for sweet-tasting, soluble carbohydrates, many of which are used in food. Simple sugars, also called monosaccharides, include...
atopic dermatitis (eczema), psoriasis, skin infection, acne, and wart. Excipients found in a topical cream formulation include thickeners, emulsifying agents...
Silicon dioxide, also known as silica, is an oxide of silicon with the chemical formula SiO2, commonly found in nature as quartz. In many parts of the...
alcohol is mainly used to: Solubilize the active ingredient(s) and some excipients Retard the crystallization of sugar Preserve the finished product Provide...
dried fruit, and some alcoholic beverages, and is permitted for use as an excipient in medications.: 4 : 16 There are no provisions for azorubine in the...
to immobilize cells and enzymes Pharmaceuticals: used as an inactive excipient in pills and tablets Soy milk and other plant milks: to thicken Diet sodas:...
of theobromine and theophylline in a naturally occurring slow-release excipient. Mate is a drink popular in many parts of South America. Its preparation...
mainly used as a tablet and capsule lubricant and as a lipidic coating excipient. It has been investigated for the encapsulation of various drugs such...
Xylitol is a chemical compound with the formula C 5H 12O 5, or HO(CH2)(CHOH)3(CH2)OH; specifically, one particular stereoisomer with that structural formula...
sweeten products, such as drinks, candies, baked goods, tobacco products, excipients, and for masking the bitter taste of some medicines. It appears as white...
which one can express but not use Inert ingredient, a component of the excipient of a pharmaceutical drug Inert munition, a round that does not contain...
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