regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
cellular response to glucose starvation
negative regulation of translation in response to stress
ossification
negative regulation of translational initiation in response to stress
phosphorylation
cellular response to amino acid starvation
chondrocyte development
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
insulin secretion
endoplasmic reticulum organization
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
ER overload response
response to manganese-induced endoplasmic reticulum stress
endoplasmic reticulum unfolded protein response
protein phosphorylation
response to unfolded protein
positive regulation of gene expression
cellular response to cold
peptidyl-serine phosphorylation
angiogenesis
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
protein autophosphorylation
positive regulation of vascular endothelial growth factor production
positive regulation of transcription by RNA polymerase I
protein homooligomerization
activation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of myelination
regulation of translation
calcium-mediated signaling
endocrine pancreas development
positive regulation of protein localization to nucleus
regulation of translational initiation by eIF2 alpha phosphorylation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9451
13666
Ensembl
ENSG00000172071
ENSMUSG00000031668
UniProt
Q9NZJ5
Q9Z2B5
RefSeq (mRNA)
NM_001313915 NM_004836
NM_010121 NM_001313918
RefSeq (protein)
NP_001300844 NP_004827
NP_001300847 NP_034251
Location (UCSC)
Chr 2: 88.56 – 88.69 Mb
Chr 6: 70.82 – 70.88 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.[5][6][7][8]
^ abcGRCh38: Ensembl release 89: ENSG00000172071 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031668 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC (December 1998). "Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control". Molecular and Cellular Biology. 18 (12): 7499–7509. doi:10.1128/MCB.18.12.7499. PMC 109330. PMID 9819435.
^Harding HP, Zhang Y, Ron D (January 1999). "Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase". Nature. 397 (6716): 271–274. Bibcode:1999Natur.397..271H. doi:10.1038/16729. PMID 9930704. S2CID 4416662.
^Hayes SE, Conner LJ, Stramm LE, Shi Y (1999). "Assignment of pancreatic eIF-2alpha kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization". Cytogenetics and Cell Genetics. 86 (3–4): 327–328. doi:10.1159/000015328. PMID 10575235. S2CID 84483593.
reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene. The protein encoded by this gene phosphorylates the alpha subunit...
Perk Thermodynamic beta, a fundamental quantity in statistical mechanics EIF2AK3, a human enzyme, often abbreviated as PERK Perk, a bonus which gives a...
kinases that phosphorylate eIF2α, including PKR-like ER kinase (PERK, EIF2AK3), heme-regulated eIF2α kinase (HRI, EIF2AK1), general control non-depressible...
NFE2L2 has been shown to interact with MAFF, MAFG, MAFK, C-jun, CREBBP, EIF2AK3, KEAP1, and UBC. Heme oxygenase Carbon monoxide-releasing molecules GRCh38:...
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